健听者汉语言多特征复合刺激下的失匹配负波研究

A Study of Mismatch Negativity in Chinese Language Multi-feature Paradigm Stimulation in Healthy Listeners

张子月;毛翔;王巍;陈鱼;王悦;吴琦

1:天津大学附属海河医院

2:天津市第一中心医院耳鼻咽喉头颈外科

3:天津市耳鼻喉科研究所

摘要
目的 应用高密度脑电配合汉语言多特征复合刺激范式探究健听者对汉语言各元素偏差刺激所引发的失匹配负波(mismatch negativity, MMN)特征,探索健听者对汉语言不同元素的感知差异。方法 设计并编写汉语言多特征复合刺激范式,采集22例健听者对汉语言声母、韵母、声调、声强和声长偏差刺激所引发的脑电数据,分析MMN波形特征,并对波幅和潜伏期进行统计分析。结果 时域分析发现,汉语言的韵母、声母、声强偏差刺激可以引出明显的MMN波形,而音调引出的MMN较弱,声长偏差刺激没有引出明显的MMN。汉语言不同元素偏差刺激引出的MMN潜伏期(P=0.044)及波幅(P<0.001)存在显著差异,韵母(180 ms)偏差刺激引出的MMN潜伏期显著小于声强(224 ms)(P=0.006),声长(-0.004μV)偏差刺激引出的MMN波幅显著小于声强(-1.81μV)(P<0.001)。结论 健听者对汉语言不同元素偏差刺激所引发的MMN波形特征存在显著差异,提示对汉语言不同元素的感知过程可能存在不同的神经机制。
关键词
高密度脑电;汉语言多特征复合刺激范式;事件相关电位;失匹配负波
基金项目(Foundation):
天津市医学重点学科(专科)建设项目(TJYXZDXK-046A);; 省部共建电工装备可靠性与智能化国家重点实验室开放课题(EERIKF2021002);; 天津市津门医学英才(TJSJMYXYC-D2-021)
作者
张子月;毛翔;王巍;陈鱼;王悦;吴琦
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