正常听力青年人言语诱发ABR与扩展高频测听的性别与年龄差异

Sex and Age Differences of Speech-evoked Auditory Brainstem Response and Extended High-frequency Audiometry in Normal Hearing Youth

毛杭泽;赵乌兰;蔡国庆;张美辨;邱伟

1:浙江中医药大学医学技术与信息工程学院

2:浙江省疾病预防控制中心

3:之江实验室

摘要
目的 探讨正常听力青年人言语声诱发听性脑干反应(speech-evoked auditory brainstem response, s-ABR)以及扩展高频测听的性别、年龄差异,旨在提供不同性别、年龄正常听力人群的参考数据。方法 招募171例(171耳)18~42周岁纯音听阈正常、无噪声暴露史的正常听力青年人,其中,女82耳,男89耳;18~30岁(大于18岁小于等于30岁)组96耳(男46耳,女50耳),30~42岁(大于30小于等于42岁)组54耳(男、女各27耳),分别进行常频及扩展高频测听、s-ABR测试,比较s-ABR各波潜伏期和幅值以及各频率阈值的差异,分析s-ABR各波潜伏期、幅值以及V/A复合体与常频及扩展高频纯音测听的相关性。结果 性别比较:(1)女性s-ABR的波V、C和F潜伏期显著短于男性(P<0.05),V/A幅值显著高于男性(P<0.05);(2)除4 kHz外,其余各频率平均听阈无明显性别差异(P>0.05)。年龄比较:(1)18~30岁组波O幅值显著高于30~42岁组(P<0.05),V/A斜率显著大于30~42岁组;(2)除0.25 kHz外,其余各频率平均听阈值18~30岁组显著低于30~42岁组(P<0.05)。相关性分析:波O幅值与PTA_(0.5~4)、PTA_(3~8)和PTA_(EHF)呈正相关(P<0.05);波A潜伏期、V/A波间期与PTA_(3~8)呈正相关(P<0.05);V/A斜率与PTA_(3~8)、PTA_(EHF)呈负相关(P<0.05)。结论 性别和年龄因素对脑干和外周听觉系统对言语声刺激的反应有不同程度的影响,高频听力对言语声精细结构判别上起作用。
关键词
言语声诱发听性脑干反应;扩展高频测听;年龄;性别
基金项目(Foundation):
美国国立失聪和其他沟通障碍研究院(NIDCD/NIH,1R01DC015990);; 浙江中医药大学校级科研基金项目(2021ZZ05);浙江中医药大学横向课题项目(20181015);; 西万拓听力奖学金项目(782299A00501)
作者
毛杭泽;赵乌兰;蔡国庆;张美辨;邱伟
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