铁死亡在耳聋疾病中的研究进展

柳铖棋;郑重;肖丽丽;夏俍;冯艳梅

1:上海交通大学附属第六人民医院耳鼻咽喉头颈外科

2:上海市睡眠呼吸障碍疾病重点实验室

摘要
<正>耳聋的病因复杂,多种程序性细胞死亡均与耳聋的发生和发展有关,单一途径抑制某种程序性细胞死亡不能阻止耳聋的发生。铁死亡是一种新型程序性死亡,以铁积聚、脂质过氧化和损伤相关分子释放为特征,应激状态下多种抗氧化系统异常导致铁依赖的脂质过氧化是其主要的发生机制。铁死亡与多个系统的生理和病理过程有关,例如癌细胞微环境、神经退行性疾病、急性肾衰竭和心脏缺血/再灌注损伤。近年铁死亡也被证实存在于药物性聋的发生机制中,
关键词
基金项目(Foundation):
国家自然科学基金(82171139);国家自然科学基金国际(地区)合作与交流项目(81720108010);; 上海市科学技术委员会(18DZ2260200)
作者
柳铖棋;郑重;肖丽丽;夏俍;冯艳梅
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