胃蛋白酶在声带息肉、声带癌中的作用分析

Analysis of the Role of Pepsin in Vocal Cord Polyp and Vocal Cord Cancer

高竞逾;罗仁婧;阮标;江超武;刘卓慧;龙瑞清;梁秋林;张策;苏路;李鹏

1:昆明医科大学第一附属医院耳鼻咽喉科

2:重庆两江新区人民医院耳鼻咽喉科

3:昆明市延安医院耳鼻咽喉科

4:昆明市延安医院普外一科

摘要
目的 探讨胃蛋白酶在声带息肉、声带癌发病中的作用。方法 选取2020年5月至2021年12月诊断为声带息肉患者27例(声带息肉组),声带癌患者27例(声带癌组),健康志愿者23例(对照组);采用反流症状指数(reflux symptom index, RSI)、反流体征评分(reflux finding score, RFS)量表进行评分,胃蛋白酶检测试剂盒(Peptest)进行唾液胃蛋白酶检测,并用免疫组织化学方法检测声带息肉、声带癌患者声带组织中胃蛋白酶表达情况,比较三组RSI、RFS评分、胃蛋白酶检测试剂盒结果,比较声带息肉组和声带癌组胃蛋白酶免疫组化染色结果。结果 声带息肉组和声带癌组的RSI、RFS、胃蛋白酶检测结果均高于对照组,差异均有统计学意义(P<0.05);声带息肉组的RSI、胃蛋白酶检测结果和胃蛋白酶免疫组化结果与声带癌组比较差异无统计学意义(P>0.05);声带息肉组的RFS与声带癌组比较差异有统计学意义(P<0.05)。结论 胃蛋白酶可能是声带息肉、声带癌的致病因素之一,但发病机制可能有所不同。
关键词
声带息肉;声带癌;胃蛋白酶
基金项目(Foundation):
昆明市卫生健康委员会卫生科研项目(2020-04-01-011)
作者
高竞逾;罗仁婧;阮标;江超武;刘卓慧;龙瑞清;梁秋林;张策;苏路;李鹏
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