红景天苷改善顺铂引起的小鼠耳蜗毛细胞和螺旋神经节神经元损伤的机制
Salidroside Modulates cAMP/PKA/CREB Signaling Pathway to Inhibit Cisplatin-induced Damages of Cochlear Hair Cells and Spiral Ganglion Neurons in Mice
李兆龙;徐义策;李泽文;周洁
1:孝感市中心医院耳鼻咽喉头颈外科
摘要关键词基金项目(Foundation):作者参考文献1 Freyer DR,Brock PR,Chang KW,et al.Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer:a clinical practice guideline[J].Lancet Child Adolesc Health,2020,4(2):141-150.
2 Tang Q,Wang X,Jin H,et al.Cisplatin-induced ototoxicity:updates on molecular mechanisms and otoprotective strategies[J].Eur J Pharm Biopharm,2021,163(1):60-71.
3 Ramkumar V,Mukherjea D,Dhukhwa A,et al.Oxidative stress and inflammation caused by cisplatin ototoxicity[J].Antioxidants (Basel),2021,10(12):1919.
4 Magani SKJ,Mupparthi SD,Gollapalli BP,et al.Salidroside—can it be a multifunctional drug[J]?Curr Drug Metab,2020,21(7):512-524.
5 于姝媛，李浩楠，朱紫嘉，等.红景天苷通过降低氧化应激介导氨基糖苷类药物耳毒性的抑制作用[J].中国听力语言康复科学杂志，2018,16(4):246-249.
6 Ding X,Wang W,Chen J,et al.Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting apoptosis[J].Toxicol Lett,2019,310(1):51-60.
7 Basch ML,Brown RM,Jen HI,et al.Where hearing starts:the development of the mammalian cochlea[J].J Anat,2016,228(2):233-254.
8 Gao X,Zhang X,Cui L,et al.Ginsenoside Rb1 promotes motor functional recovery and axonal regeneration in post-stroke mice through cAMP/PKA/CREB signaling pathway[J].Brain Res Bull,2020,154(1):51-60.
9 Yang Y,Ma S,Wei F,et al.Pivotal role of cAMP-PKA-CREB signaling pathway in manganese-induced neurotoxicity in PC12 cells[J].Environ Toxicol,2019,34(9):1052-1062.
10 Mei H,Zhao L,Li W,et al.Inhibition of ferroptosis protects house ear institute-organ of corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity[J].J Cell Mol Med,2020,24(20):12065-12081.
11 Kim YJ,Lee JS,Kim H,et al.Gap junction-mediated intercellular communication of cAMP prevents CDDP-induced ototoxicity via cAMP/PKA/CREB pathway[J].Int J Mol Sci,2021,22(12):6327-6337.
12 Breglio AM,Rusheen AE,Shide ED,et al.Cisplatin is retained in the cochlea indefinitely following chemotherapy[J].Nat Commun,2017,8(1):1654-1662.
13 Gentilin E,Simoni E,Candito M,et al.Cisplatin-induced ototoxicity:updates on molecular targets[J].Trends Mol Med,2019,25(12):1123-1132.
14 Zhang X,Zhang Y,Li R,et al.Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis[J].Aging (Albany NY),2020,12(10):9405-9426.
15 Hu M,Zhang D,Xu H,et al.Salidroside activates the AMP-activated protein kinase pathway to suppress nonalcoholic steatohepatitis in mice[J].Hepatology,2021,74(6):3056-3073.
16 Jewell JL,Fu V,Hong AW,et al.GPCR signaling inhibits mTORC1 via PKA phosphorylation of raptor[J].Elife,2019,8(1):e43038.
17 Sisakht M,Khoshdel Z,Mahmoodazdeh A,et al.Adrenomedullin increases cAMP accumulation and BDNF expression in rat DRG and spinal motor neurons[J].Iran J Basic Med Sci,2021,24(7):978-985.
18 Li S,Lu Y,Ding D,et al.Fibroblast growth factor 2 contributes to the effect of salidroside on dendritic and synaptic plasticity after cerebral ischemia/reperfusion injury[J].Aging (Albany NY),2020,12(11):10951-10968.
19 Yan J,Xu W,Lenahan C,et al.CCR5 activation promotes NLRP1-dependent neuronal pyroptosis via CCR5/PKA/CREB pathway after intracerebral hemorrhage[J].Stroke,2021,52(12):4021-4032.
20 Chen X,Wu Y,Yang T,et al.Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling[J].J Cachexia Sarcopenia Muscle,2016,7(2):225-232.
21 冯晓玲，孙佳宁，赵小萱.红景天苷联合顺铂对人卵巢癌SKOV-3裸鼠移植瘤生长影响及其机制研究[J].中华中医药杂志，2021,36(7):3851-3855.