帕金森病患者的语音声学特征分析

Study of Voice Acoustic Characteristics in Patients with Parkinson's Disease

文鹏程;张峪涵;文贵华

1:湖北民族学院

2:东莞市松山湖中心医院神经内科

3:华南理工大学

摘要
目的 分析帕金森病(PD)患者的语音声学特征,初步探索声学指标与PD的相关性。方法 共纳入2021年1月至2022年1月于东莞市松山湖中心医院确诊的PD患者83例作为PD组,健康体检者87例作为正常对照组。对帕金森病患者根据统一帕金森病综合评分量表(unified Parkinson's disease rating scale, UPDRS)进行评估。采集所有研究对象的声音样本,利用语音处理软件提取声学特征指标。按照性别分组比较研究对象的声学特征指标,并分析PD患者声学特征指标与UPDRS评分的相关性。结果 共收集受试者语音样本3 720个,其中PD组1 895个,对照组1 825个。PD组的最大基频、基频范围及基频周期变化率低于正常对照组,振幅扰动高于正常对照组,差异均有统计学意义(均为P<0.05)。女性PD患者基频周期变化率与UPDRS-Ⅲ评分呈负相关(r=-0.617,P<0.05)。结论 PD患者语音声学变化主要表现为最大基频、基频范围及基频周期变化率降低,振幅扰动增高;基频周期变化率可能用于协助评估女性PD患者病情变化。
关键词
帕金森病;语音障碍;言语声学
基金项目(Foundation):
广东省医学科研基金项目(B2021446);; 东莞市社会发展重点项目(202050715024222)资助
作者
文鹏程;张峪涵;文贵华
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文鹏程张峪涵文贵华