肌醇需求酶1对顺铂所致小鼠耳蜗毛细胞凋亡的作用研究
Effect of Inositol-requiring Enzyme 1 on Cisplatin-induced Apoptosis of Cochlear Hair Cells in Mouse
张晓;王爱梅
1:河南护理职业学院解剖学教研室
2:锦州医科大学生理学教研室
摘要关键词基金项目(Foundation):作者参考文献1 Gentilin E,Simoni E,Candito M,et al.Cisplatin-induced ototoxicity:updates on molecular targets[J].Trends in Molecular Medicine,2019,25(12):1123-1132.
2 Tang Q,Wang X,Jin H,et al.Cisplatin-induced ototoxicity:updates on molecular mechanisms and otoprotective strategies[J].European Journal of Pharmaceutics and Biopharmaceutics,2021,163:60-71.
3 张晓，周明生，于利等.内质网应激在顺铂诱导离体小鼠耳蜗毛细胞凋亡中的作用[J].听力学及言语疾病杂志，2016,24(1):54-57.
4 Marciniak SJ,Chambers JE,Ron D.Pharmacological targeting of endoplasmic reticulum stress in disease[J].Nature Reviews Drug Discovery,2022,21(2):115-140.
5 Zhao NA,Cao J,Xu L,et al.Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer[J].The Journal of Clinical Investigation,2018,128(4):1283-1299.
6 Kros CJ,Steyger PS.Aminoglycoside-and cisplatin-induced ototoxicity:mechanisms and otoprotective strategies[J].Cold Spring Harbor Perspectives in Medicine,2019,9(11):1-18.
7 Hazlitt RA,Min J,Zuo J.Progress in development of preventative drugs for cisplatin-induced hearing loss[J].Journal of Medicine Chemistry,2018,61(13):5512-5524.
8 李幸幸，刘俊，徐忠诚，等.复方丹参滴丸通过调控IRE1-TRAF2-ASK1-JNK通路降低内质网应激和自噬保护血管平滑肌细胞[J].中国药理学通报，2022,38(5):776-783.
9 Siwecka N,Rozp?dek-Kamińska W,Wawrzynkiewicz A,et al.The structure,activation and signaling of IRE1 and its role in determining cell fate[J].Biomedicines,2021,9(2):1-29.
10 Adams CJ,Kopp MC,Larburu N,et al.Structure and molecular mechanism of ER stress signaling by the unfolded protein response signal activator IRE1[J].Frontiers in Molecular Biosciences,2019,6(11):1-12.
11 Nakano R,Nakayama T,Sugiya H.Biological properties of JNK3 and its function in neurons,astrocytes,pancreatic β-cells and cardiovascular cells[J].Cells,2020,9(8):1-19.
12 Wang M,Hayashi H,Horinokita I,et al.Neuroprotective effects of Senkyunolide I against glutamate-induced cells death by attenuating JNK/caspase-3 activation and apoptosis[J].Biomedicine & Pharmacotherapy,2021,140:1-8.
13 Tu Y,Fan G,Sun H,et al.Endoplasmic reticulum stress is involved in spiral ganglion neuron apoptosis following chronic kanamycin-induced deafness[J].Bioscience Reports,2019,39(2):1-12.