PD98059抑制大鼠听泡成骨细胞增殖及分化
PD98059 Inhibits the Proliferation and Differentiation of Osteoblasts in Rat Otocyst
黄玉;刘豆;黄文霞;梁耕田
1:武汉大学附属同仁医院(武汉市第三医院)耳鼻咽喉-头颈外科





1 Forseni FM,Hultcrantz M.Possible inflammatory mediators in tympanosclerosis development[J].Int J Pediatr Otorhinolaryngol,2002,63(2):149-154.
2 Milojevic M,Djeric D,Bijelic D.Prognostic significance of tympanosclerotic plaques localization and their morphological and histological characteristics for the outcome of surgical treatment[J].Vojnosanit Pregl,2012,69(2):190-194.
3 Boyce BF,Xing L.Functions of RANKL/RANK/OPG in bone modeling and remodeling[J].Arch Biochem Biophys,2008,473(2):139-146.
4 黄宏明,吴佩娜,崔勇,等.OPG和RANKL在大鼠鼓室硬化模型中的表达[J].中华耳科学杂志,2013,11(2):302-305.
5 Noguchi T,Ebina K,Hirao M,et al.Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1/2 pathway and by suppressing osteoclast differentiation via c-Fos,NFATc1,and NF-kappaB pathway[J].Biochem Biophys Res Commun,2018,503(2):644-650.
6 Liu H,Zheng X,Chen L,et al.Negative pressure wound therapy promotes muscle-derived stem cell osteogenic differentiation through MAPK pathway[J].J Cell Mol Med,2018,22(1):511-520.
7 Cheng ZY,Ye T,Ling QY,et al.Parathyroid hormone promotes osteoblastic differentiation of endothelial cells via the extracellular signal-regulated protein kinase 1/2 and nuclear factor-kappaB signaling pathways[J].Exp Ther Med,2018,15(2):1754-1760.
8 Wanachewin O,Boonmaleerat K,Pothacharoen P,et al.Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways[J].BMC Complement Altern Med,2012,12:71.
9 Huang Y,Wang X,Wu F,et al.The possible role of sclerostin in the pathogenesis of tympanosclerosis[J].Audiol Neurootol,2021,26(2):102-110.
10 安秋霞,蒙艳丽,吕丹丹,等.丝裂原活化蛋白激酶信号通路的研究进展[J].黑龙江中医药,2016,45(5):65-66.
11 Hutton SR,Otis JM,Kim EM,et al.ERK/MAPK signaling is required for pathway-specific striatal motor functions[J].J Neurosci,2017,37(34):8102-8115.
12 Armstrong SC.Protein kinase activation and myocardial ischemia/reperfusion injury[J].Cardiovasc Res,2004,61(3):427-436.
13 Oh WJ,Jung U,Eom HS,et al.Inhibition of lipopolysaccharide-induced proinflammatory responses by buddleja officinalis extract in BV-2 microglial cells via negative regulation of NF-kB and ERK1/2 signaling[J].Molecules,2013,18(8):9195-9206.
14 Abarikwu SO.Kolaviron,a natural flavonoid from the seeds of Garcinia kola,reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion,and inflammatory transcription factors,ERK1/2,NF-kappaB,p38,Akt,p-c-JUN and JNK[J].Biochim Biophys Acta,2014,1840(7):2373-2381.
15 Wei N,Zhang C,He H,et al.Protective effect of saponins extract from Panax japonicus on myocardial infarction:involvement of NF-kappaB,Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation[J].J Pharm Pharmacol,2014,66(11):1641-1651.
16 White A,Lamb PW,Barrett JC.Frequent downregulation of the KAI1(CD82) metastasis suppressor protein in human cancer cell lines[J].Oncogene,1998,16(24):3143-3149.
17 Mashimo T,Watabe M,Hirota S,et al.The expression of the KAI1 gene,a tumor metastasis suppressor,is directly activated by p53[J].Proc Natl Acad Sci USA,1998,95(19):11307-11311.
18 王晓霞,黄常志.骨唾液酸蛋白与肿瘤[J].国外医学(肿瘤学分册),2004,31(2):111-114.
19 葛宇翔,滕华建,蒋青.Runt相关转录因子2基因在骨骼发育及间充质干细胞分化中的作用进展[J].中华实验外科杂志,2019,36(1):182-186.
20 董苑,杨瑞年,王福科,等.BMP2的表达对联合培养体系中骨髓间充质干细胞增殖和成骨分化的影响[J].中华显微外科杂志,2013,36(4):352-355.