噪声性听力损失机制研究方法及药物治疗进展

Progression on Research Methods of Noise-induced Hearing Loss Mechanism and Drug Treatment

孙韬;李悦淇;石科;杨亮;闫秀明;邱伟;郭丹

1:河南医学高等专科学校聋病机制医学重点实验室

2:郑州大学医学院临床医学系

3:河南医学高等专科学校检验学院

4:Auditory Research Laboratory

摘要
噪声性听力损失(noise-induced hearing loss, NIHL)是一项亟待解决的公共卫生问题。在所有听力损失中,有近1/3的听力损失可以归因为噪声暴露。NIHL的分子机制复杂,目前还没有特效药物能够预防和治疗NIHL,因此建立标准化的NIHL临床前研究模型、识别治疗的分子靶点,以有效开展NIHL的预防和药物治疗显得尤为重要。本文对NIHL的研究方法及药物治疗研究进行梳理总结,为NIHL的防治提供参考。
关键词
噪声性听力损失;动物模型;分子机制;分子靶点
基金项目(Foundation):
河南省高等学校重点科研项目计划(20A320006);; 河南医学高等专科学校科研团队(HNYZ2019001);; 河南省医学重点实验室(河南省聋病机制医学实验室);; 美国国立失聪和其他沟通障碍研究院资助(NIH-NIDCD,R01DC015990);; 河南省科技攻关项目(222102310338);; 河南省医学科技攻关省部共建重点项目(SBGJ202102055)
作者
孙韬;李悦淇;石科;杨亮;闫秀明;邱伟;郭丹
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