抑郁在老年人听力减退与语言功能中的中介效应

Mediating Effects of Depression in Hearing Loss and Language Function in the Elderly

程曦;曾燕;徐恒;刘丹;程桂荣

1:武汉科技大学医学院脑科学先进技术研究院

摘要
目的 研究老年人听力减退对语言功能的影响及抑郁在听力减退与语言功能中的中介效应,为老年人语言功能损害的干预提供参考。方法 收集2018~2022年湖北老年记忆队列(HAMCS)中6 002名≥65岁老年人语言功能筛查的相关数据,采用多因素Logistic回归模型分析听力减退对语言功能的影响,采用Bootstrap法分析抑郁评分在听力减退影响语言功能中的中介效应。结果 6 002名≥65岁老年人中,轻度听力减退1 137例(18.94%),中-重度听力减退264例(4.40%),语言功能损害2 611例(43.50%);在控制了年龄、受教育年限、婚姻状况、居住地、体育锻炼、智力活动、高血压、冠心病和脑血管病等混杂因素后,多因素Logistic回归分析结果显示:轻度听力减退、中-重度听力减退老年人语言功能损害的患病风险分别为听力正常老年人的1.33倍(95%CI:1.13~1.56,P=0.001)、1.77倍(95%CI:1.29~2.42,P<0.001);中介效应分析结果显示:抑郁在听力减退和语言功能损害之间起部分中介作用,中介效应量为-0.021(95%CI:-0.027~-0.015,P<0.001),占总效应的12.96%。结论 老年人听力减退可增加语言功能损害的患病风险,其中抑郁在听力减退和语言功能损害之间起部分中介作用。
关键词
听力减退;语言功能损害;抑郁;中介效应;老年人
基金项目(Foundation):
国家重点研发计划(2020YFC2006000);; 国家自然科学基金(72174159)
作者
程曦;曾燕;徐恒;刘丹;程桂荣
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