M_1/M_2小胶质细胞参与急性耳鸣中枢发病机制的研究进展

Research Progress of M_1/M_2 Microglia Involved in Central Pathogenesis of Acute Tinnitus

夏晴;张剑宁

1:上海中医药大学附属岳阳中西医结合医院耳鼻咽喉科

摘要
小胶质细胞(microglia cell)是中枢神经系统特有的巨噬细胞,在神经损伤、修复及重塑过程中起重要作用。而中枢听觉通路及边缘系统等功能异常、神经结构及神经重塑是耳鸣中枢机制关注的焦点。M1和M2型小胶质细胞分别通过促炎、抗炎反应参与神经重塑。近年来研究发现小胶质细胞通过释放相关细胞因子,参与急性耳鸣发病过程,但具体机制尚不明确。本文对M1和M2小胶质细胞在急性耳鸣中枢机制中的研究进展进行综述。
关键词
耳鸣;M1/M2小胶质细胞;炎症;神经营养因子
基金项目(Foundation):
作者
夏晴;张剑宁
参考文献

1 Tang D,Li H,Chen L,Advances in understanding,diagnosis,and treatment of tinnitus[J].Adv Exp Med Biol,2019,1130:109-128.

2 Xia C,Yin M,Wu C,et al.Neuroglial activation in the auditory cortex and medial geniculate body of salicylate-induced tinnitus rats[J].Am J Transl Res,2020,12(10):6043-6059.

3 Tanaka M,Sackett S,Zhang Y.Endocannabinoid modulation of microglial phenotypes in neuropathology[J].Frontiers in Neurology,2020,11(87):1-17.

4 Sominsky L,De Luca S,Spencer S.Microglia:key players in neurodevelopment and neuronal plasticity[J].The International Journal of Biochemistry & Cell Biology,2018,94:56-60.

5 Wolf S,Boddeke H,Kettenmann H.Microglia in physiology and disease[J].Annual Review of Physiology,2017,79:619-643.

6 Baizer JS,Wong KM,Manohar S,et al.Effects of acoustic trauma on the auditory system of the rat:The role of microglia[J].Neuroscience,2015,303:299-311.

7 Fuentes-Santamaria V,Alvarado J C,Melgar-Rojas P,et al.The role of glia in the peripheral and central auditory system following noise overexposure:contribution of TNF-alpha and IL-1beta to the pathogenesis of hearing loss[J].Front Neuroanat,2017,11(9):1-26.

8 Li J,Shui X,Sun R,et al.Microglial phenotypic transition:signaling pathways and influencing modulators involved in regulation in central nervous system diseases[J].Frontiers in Cellular Neuroscience,2021,15:1-16.

9 纪波波,李明,张剑宁.功能性磁共振成像应用于耳鸣机制研究进展[J].中华耳鼻咽喉头颈外科杂志,2018,53 (2):150-154.

10 徐飘,杨静雅,林琼萍,等.精细化声治疗耳鸣的疗效分析[J].听力学及言语疾病杂志,2021,29 (6):653-657.

11 Arcuri C,Mecca C,Bianchi R,et al.The pathophysiological role of microglia in dynamic surveillance,phagocytosis and structural remodeling of the developing CNS[J].Frontiers in Molecular Neuroscience,2017,10(191):1-22.

12 Wang W,Zhang LS,Zinsmaier AK,et al.Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models[J].PLoS Biol,2019,17 (6):1-25.

13 Chen X,Zheng L.Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus[J].Molecular Medicine Reports,2017,16 (4):5643-5648.

14 Hu S,Mei L,Chen J,et al.Effects of salicylate on the inflammatory genes expression and synaptic ultrastructure in the cochlear nucleus of rats[J].Inflammation,2014,37 (2):365-373.

15 肖倩文,左健,葛佳丽,等.水杨酸钠诱导耳鸣大鼠海马中TNF-α、IL-1β的表达[J].听力学及言语疾病杂志,2020,28 (5):540-544.

16 Hwang JH,Huang DC,Lu YC,et al.Effects of tumor necrosis factor blocker on salicylate-induced tinnitus in mice[J].Int Tinnitus J,2017,21 (1):24-29.

17 Hwang JH,Chen JC,Yang SY,et al.Expression of tumor necrosis factor-alpha and interleukin-1beta genes in the cochlea and inferior colliculus in salicylate-induced tinnitus[J].J Neuroinflammation,2011,8(1):30-35.

18 胡守森,梅玲,陈建勇,等.水杨酸盐毒性与大鼠耳蜗核炎症因子表达[J].中华耳科学杂志,2015,13 (1):136-140.

19 Dey A,Hankey Giblin P.Insights into macrophage heterogeneity and cytokine-induced neuroinflammation in major depressive disorder[J].Pharmaceuticals (Basel,Switzerland),2018,11 (3):64-80.

20 Szczepek A,Haupt H,Klapp B,et al.Biological correlates of tinnitus-related distress:an exploratory study[J].Hearing Research,2014,318:23-30.

21 陈秀兰,宋凡,秦兆冰,等.耳鸣严重程度与焦虑、抑郁及人格特征的相关性[J].听力学及言语疾病杂志,2021,29 (4):444-446.

22 Burmeister A,Marriott I.The interleukin-10 family of cytokines and their role in the CNS[J].Frontiers in Cellular Neuroscience,2018,12(458):1-13.

23 Haider H,Ribeiro S,Martins C,et al.Tinnitus,hearing loss and inflammatory processes in an older portuguese population[J].International Journal of Audiology,2020,59 (5):323-332.

24 Coskunoglu A,Orenay-Boyacioglu S,Deveci A,et al.Evidence of associations between brain-derived neurotrophic factor (BDNF) serum levels and gene polymorphisms with tinnitus[J].Noise & Health,2017,19 (88):140-148.

25 Hu S,Mei L,Chen J,et al.Expression of immediate-early genes in the dorsal cochlear nucleus in salicylate-induced tinnitus[J].European Archives of Oto-Rhino-Laryngology,2016,273(2):325-332.

26 Panford-Walsh R,Singer W,Rüttiger L,et al.Midazolam reverses salicylate-induced changes in brain-derived neurotrophic factor and arg3.1 expression:implications for tinnitus perception and auditory plasticity[J].Molecular Pharmacology,2008,74 (3):595-604.

27 Yi B,Wu C,Shi R,et al.Long-term administration of salicylate-induced changes in BDNF expression and CREB phosphorylation in the auditory cortex of rats[J].Otology & Neurotology,2018,39(3):e173-e180.

28 Xiong H,Yang H,Liang M,et al.Plasma brain-derived neurotrophic factor levels are increased in patients with tinnitus and correlated with therapeutic effects[J].Neuroscience Letters,2016,622:15-18.

29 Goto F,Saruta J,Kanzaki S,et al.Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus[J].Neuroscience Letters,2012,510 (2):73-77.

30 Orihuela R,Mcpherson C,Harry G.Microglial M1/M2 polarization and metabolic states[J].British Journal of Pharmacology,2016,173 (4):649-665.

31 Du L,Zhang Y,Chen Y,et al.Role of microglia in neurological disorders and their potentials as a therapeutic target[J].Mol Neurobiol,2017,54 (10):7567-7584.

32 Abd-Elhakim Y,Moselhy A,Aldhahrani A,et al.Protective effect of curcumin against sodium salicylate-induced oxidative kidney damage,nuclear factor-kappa dysregulation,and apoptotic consequences in rats[J].Antioxidants (Basel,Switzerland),2021,10 (6):826-843.

33 Yao K,Zhao Y.Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice[J].Experimental Gerontology,2018,111:86-93.

34 Zhang Y,Zhao Y,Zhang J,et al.Ginkgolide B inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization in Aβ-induced microglia cells[J].Neuroscience Letters,2021,764:1-9.

本文信息

PDF(153K)

本文作者相关文章

夏晴张剑宁