阿尔茨海默病患者自发言语的停顿特征

The Pause Characteristics of Self Speaking in Alzheimer's Disease Patients

李欣雨;于佳燕;肖永涛

1:浙江中医药大学医学技术与信息工程学院

摘要

目的探讨轻中度阿尔茨海默病(Alzheimer's disease, AD)患者的自发言语停顿特征。方法选取简易智力状态检查(minimum mental state examination, MMSE)量表得分10～20分、且病程6个月～5年的轻中度AD患者20例作为AD组，年龄相匹配、认知功能正常受试者25例作为对照组。两组受试者分别进行自发言语表达，选取1 min连续音频，记录停顿总数，按停顿时长分为短时停顿(0.25 s≤t<0.50 s)、中时停顿(0.50 s≤t<0.90 s)、长时停顿(0.90 s≤t<2.00 s)和暂停(>2.00 s),计算各停顿类型均值，比较两组结果，对MMSE得分与停顿数量进行相关回归分析。结果 AD组的短时停顿数量显著少于对照组(P<0.05),长时停顿、暂停的数量显著多于对照组(P<0.05);两组间中时停顿、总停顿的数量无统计学差异(P>0.05)。AD组内短时停顿的数量少于中时停顿和长时停顿(P<0.05);AD组中，中时停顿数量对MMSE得分有正向预测作用(β=0.515,P<0.05),暂停数量对MMSE有负向预测作用(β=-0.626,P<0.01)。结论轻中度AD患者在自发言语中产生时间较长停顿的频率更高，产生时间较短停顿的频率较低；认知水平较高的AD患者会产生更多时间较短的停顿，认知水平较低的AD患者会产生更多时间较长的停顿。

关键词

阿尔茨海默病;自发言语;停顿

基金项目(Foundation):

作者

李欣雨;于佳燕;肖永涛

参考文献

1 Singh S,Bucks RS,Cuerden JM.Evaluation of an objective technique for analysing temporal variables in DAT spontaneous speech[J].Aphasiology,2001,15(6):571-583.

2 Croot K,Hodges JR,Xuereb J,et al.Phonological and articulatory impairment in Alzheimer's disease:a case series[J].Brain and Language,2000,75(2):277-309.

3 Pistono A,Jucla M,Barbeau EJ,et al.Pauses during autobiographical discourse reflect episodic memory processes in early Alzheimer's disease[J].Journal of Alzheimer's Disease,2016,50(3):687-698.

4 Beltrami D,Gagliardi G,Rossini Favretti R,et al.Speech analysis by natural language processing techniques:a possible tool for very early detection of cognitive decline[J]?Frontiers in Aging Neuroscience,2018,10:369.

5 于帆，李甦.正常和听障儿童口语叙事中的停顿研究[J].听力学及言语疾病杂志，2015,23(5):546-548.

6 惠芬芬，万勤，高晓慧，等.学龄前听障儿童助听后言语流畅性的特征及影响因素[J].听力学及言语疾病杂志，2017,25(4):410-414.

7 Alzheimer's Association.2018 Alzheimer's disease facts and figures[J].Alzheimer's & Dementia,2018,14(3):367-429.

8 Imre N,Balogh R,Gosztolya G,et al.Temporal speech parameters indicate early cognitive decline in elderly patients with type 2 diabetes mellitus[J].Alzheimer Disease and Associated Disorders,2022,36(2):148-155.

9 Gayraud F,Lee HR,Barkat-Defradas M.Syntactic and lexical context of pauses and hesitations in the discourse of Alzheimer patients and healthy elderly subjects[J].Clinical Linguistics & Phonetics,2011,25(3):198-209.

10 Hoffmann I,Nemeth D,Dye CD,et al.Temporal parameters of spontaneous speech in Alzheimer's disease[J].International Journal of Speech-Language Pathology,2010,12(1):29-34.

11 Yohannes AM,Chen W,Moga AM,et al.Cognitive impairment in chronic obstructive pulmonary disease and chronic heart failure:a systematic review and meta-analysis of observational studies[J].Journal of the American Medical Directors Association,2017,18(5):451.e1-451.e11.

12 姚剑鹏.自然言语中的语流暂停研究及其认知功用分析[J].外语教学理论与实践，2006,26(3):6-13.

13 Salehi M,Reisi M,Ghasisin L.Lexical retrieval or semantic knowledge?which one causes naming errors in patients with mild and moderate Alzheimer's disease[J]?Dementia and Geriatric Cognitive Disorders EXTRA,2017,7(3):419-429.

14 Kim KW,Na SH,Chung YC,et al.A comparison of speech features between mild cognitive impairment and healthy aging groups[J].Dementia and Neurocognitive Disorders,2021,20(4):52-61.

15 Shea C,Leonard K.Evaluating measures of pausing for second language fluency research[J].The Canadian Modern Language Review,2019,75:216-235.

16 刘楚群.口语非流利产出与衰老关联度研究[J].井冈山大学学报(社会科学版),2020,41(5):108-114.

17 刘楚群.老年人口语“呃”类填塞语研究[J].语言战略研究，2020,5(1):78-89.

18 王希竹，金晓艳.韩国留学生口语产出非流利停顿现象研究[J].东疆学刊，2021,38(3):120-126.

本文信息

PDF(272K)

本文关键词相关文章

阿尔茨海默病自发言语停顿

本文作者相关文章

李欣雨于佳燕肖永涛