水合氯醛应用于儿童ABR检测的安全性和有效性研究

Safety and Effectiveness of Chloral Hydrate for Auditory Brainstem Response Tests in Children

张湘玲;姚心怡;刘敏;金悠悠;孟照莉;刘昊天;郑芸

1:四川大学华西医院耳鼻咽喉-头颈外科

摘要
目的 分析水合氯醛应用于儿童听性脑干反应(ABR)检测的安全性和有效性。方法 选取2015年12月至2022年3月在四川大学华西医院接受水合氯醛镇静(剂量30 mg/kg)进行ABR检查、年龄小于12岁的患儿5 513例次(≤0.5岁2 509例次、0.5~3岁2 548例次、3~12岁546例次)为研究对象。回顾性分析镇静失败患者喂服方式(混合或直接喂服)、睡眠剥夺(是或否)、镇静失败表现(如无法入睡、镇静不足、浅睡眠状态)、不良事件(呕吐、烦躁等)等资料。计算总镇静失败率、不同年龄组镇静失败率及不良事件发生率。结果 5 513例次中镇静失败199例次(3.61%),上述不同年龄组镇静失败率分别为3.03%、4.31%、3.11%。199例次中,81.91%例次表现为镇静不足。不良事件发生率为10.55%,其中呕吐最常见。结论 本研究对儿童ABR检测时镇静失败率及不良事件发生率相对既往国内外研究较低,可认为水合氯醛在此剂量安全有效。
关键词
水合氯醛;听性脑干反应;镇静失败
基金项目(Foundation):
四川大学华西医院临床研究基金(2023HXFH018)
作者
张湘玲;姚心怡;刘敏;金悠悠;孟照莉;刘昊天;郑芸
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