不同认知负荷下年轻人言语过程中大脑皮质激活区域和功能连接性的差异分析

Analysis of Differences in Cortical Activation Areas and Functional Connectivity During Speech in Young People Under Different Cognitive Loads

江紫辉;陈秀恩;郑洁皎;郑拥军;张云云;刘向云;仇丽雯;张晨晨;宁志超

1:复旦大学附属华东医院

2:上海体育大学

3:上海中医药大学附属岳阳中西医结合医院

4:上海第四康复医院

摘要
目的 研究不同认知负荷下言语时年轻人大脑皮质激活和功能连接性的差异。方法 21例受试者(平均年龄21.9±1.33岁)分别在一致条件(颜色词语与其字体颜色相对应)和不一致条件(颜色词语与其字体颜色不相对应)下朗读嵌入了颜色词语的短句,颜色词语要求读字体的颜色而不是词语本身的读音。采用功能性近红外光谱成像技术(functional near-infrared spectroscopy, fNIRS)分析大脑左右的背外侧前额叶皮质(dorsolateral prefrontal cortex, DLPFC)以及左右的辅助运动区皮质(supplementary motor area, SMA)的皮质激活程度[含氧血红蛋白(HbO)浓度变化]和功能连接(脑区间HbO的值的Pearson相关性)差异。结果 fNIRS结果显示,与一致条件下相比较,在不一致条件下,R-DLPFC(t=3.4,P=0.003)、L-DLPFC(t=2.58,P=0.019)、R-SMA(t=3.59,P=0.002)和L-SMA(t=4.06,P=0.001)HbO浓度变化均显著升高,且R-DLPFC与L-DLPFC间的相关性显著增强(t=2.44,P=0.025),但左、右SMA之间以及SMA与DLPFC之间的相关性差异无统计学意义(P>0.05)。结论 在不一致条件下进行言语时,由于认知负荷增加,DLPFC和SMA的皮质激活程度增加,且左、右DLPFC之间的功能连接强度增加。
关键词
认知负荷;功能性近红外光谱成像技术;皮质激活;功能连接
基金项目(Foundation):
上海市卫健委面上项目(202240256);; 上海康复医学临床医学研究中心项目(21MC1930200);; 华东医院横向课题;华东医院重点学科建设(LCZX2206)
作者
江紫辉;陈秀恩;郑洁皎;郑拥军;张云云;刘向云;仇丽雯;张晨晨;宁志超
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