水杨酸盐致大鼠耳鸣相关神经通路递质变化的初步研究
A Preliminary Study on the Changes of Neurotransmitters in Neural Pathways Related to Tinnitus Induced by Salicylate in Rats
易彬;马青坪;汪雪玲;刘辉辉;顾佳怡;杜婷婷;王文枭;石润杰;黄治物
1:上海交通大学医学院附属第九人民医院耳鼻咽喉-头颈外科
2:上海交通大学医学院耳科学研究所
3:上海市耳鼻疾病转化医学重点实验室
摘要关键词基金项目(Foundation):作者参考文献[1] WU C,BAO W,YI B,et al.Increased metabolic activity and hysteretic enhanced GABAA receptor binding in a rat model of salicylate-induced tinnitus[J].Behav Brain Res,2019,364:348-355.
[2] YI B,WU C,SHI R,et al.Long-term administration of salicylate-induced changes in BDNF expression and CREB phosphorylation in the auditory cortex of rats[J].Otol Neurotol,2018,39(3):e173-e180.
[3] CAMPBELL S,MACQUEEN G.The role of the hippocampus in the pathophysiology of major depression[J].J Psychiatry Neurosci,2004,29(6):417-426.
[4] BAGULEY D,MCFERRAN D,HALL D.Tinnitus[J].Lancet,2013,382(9904):1600-1607.
[5] LANGGUTH B,KREUZER P M,KLEINJUNG T,et al.Tinnitus:causes and clinical management[J].Lancet Neurol,2013,12(9):920-930.
[6] SHORE S E,ROBERTS L E,LANGGUTH B.Maladaptive plasticity in tinnitus—triggers,mechanisms and treatment[J].Nat Rev Neurol,2016,12(3):150-160.
[7] BROZOSKI T,ODINTSOV B,BAUER C.Gamma-aminobutyric acid and glutamic acid levels in the auditory pathway of rats with chronic tinnitus:a direct determination using high resolution point-resolved proton magnetic resonance spectroscopy (H-MRS)[J].Front Syst Neurosci,2012,6:9.
[8] ELGOYHEN A B,LANGGUTH B,DE RIDDER D,et al.Tinnitus:perspectives from human neuroimaging[J].Nat Rev Neurosci,2015,16(10):632-642.
[9] JIN Y,LUO B,SU Y Y,et al.Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus[J].PLoS One,2015,10(5):e0126956.
[10] LU J,LOBARINAS E,DENG A,et al.GABAergic neural activity involved in salicylate-induced auditory cortex gain enhancement[J].Neuroscience,2011,189:187-198.
[11] YI B,HU S,ZUO C,et al.Effects of long-term salicylate administration on synaptic ultrastructure and metabolic activity in the rat CNS[J].Sci Rep,2016,6:24428.
[12] NAMIKAWA M,SANO A,TATENO T.Salicylate-induced suppression of electrically driven activity in brain slices from the auditory cortex of aging mice[J].Front Aging Neurosci,2017,9:395.
[13] NORENA A J,MOFFAT G,BLANC J L,et al.Neural changes in the auditory cortex of awake guinea pigs after two tinnitus inducers:salicylate and acoustic trauma[J].Neuroscience,2010,166(4):1194-1209.
[14] HU S S,MEI L,CHEN J Y,et al.Expression of immediate-early genes in the dorsal cochlear nucleus in salicylate-induced tinnitus[J].Eur Arch Otorhinolaryngol,2016,273(2):325-332.
[15] MULDERS W H,BARRY K M,ROBERTSON D.Effects of furosemide on cochlear neural activity,central hyperactivity and behavioural tinnitus after cochlear trauma in guinea pig[J].PLoS One,2014,9(5):e97948.
[16] LOBARINAS E,HAYES S H,ALLMAN B L.The gap-startle paradigm for tinnitus screening in animal models:limitations and optimization[J].Hear Res,2013,295:150-160.
[17] WU C,WU X,YI B,et al.Changes in GABA and glutamate receptors on auditory cortical excitatory neurons in a rat model of salicylate-induced tinnitus[J].Am J Transl Res,2018,10(12):3941-3955.
[18] 易彬，鲍伟奇，石润杰，等.水杨酸盐对大鼠听觉中枢代谢功能影响的研究[J].听力学及言语疾病杂志，2018,26(1):73-77.
[19] CROW J M.Biomedicine:move over,morphine[J].Nature,2016,535(7611):S4-6.