线粒体自噬在感音神经性听力损失发病机制中的研究进展

Research progress of mitophagy in the pathogenesis of sensorineural hearing loss

周颖东;张梦娴;王青玲;康浩然;郭向东

1:河南中医药大学第一临床医学院

2:河南中医药大学第一附属医院耳鼻喉科

摘要
线粒体自噬是在线粒体毒性条件下选择性降解受损线粒体的过程,在线粒体质量和数量控制中起着至关重要的作用。异常的线粒体自噬可导致或加重线粒体功能障碍,与许多疾病的发病机制密切相关。由于耳蜗毛细胞对能量代谢高度敏感,线粒体自噬在维持毛细胞的正常功能方面起着重要作用。线粒体自噬功能障碍导致的线粒体损伤涉及多种感音神经性听力损失的病理生理机制,本文综述了该发病机制的最新研究进展,以更好地了解线粒体自噬在听觉系统中的作用,为未来开展线粒体靶向治疗研究提供理论基础。
关键词
感音神经性听力损失;线粒体自噬;氧化应激
基金项目(Foundation):
国家自然科学基金(81403439);; 河南省科技攻关计划(222102310604);; 河南省中医药科学研究专项重点课题(20-21ZY1045);; 河南省高等学校重点科研项目(23A360028)
作者
周颖东;张梦娴;王青玲;康浩然;郭向东
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