肿瘤坏死因子-α与急性耳鸣的中枢机制探讨

Tumor necrosis factor- α and central mechanism of acute tinnitus

徐智辉;霍岩;凌雯琛;张剑宁

1:上海中医药大学附属岳阳中西医结合医院耳鼻喉科

摘要
耳鸣发病机制不明,可能涉及外周及中枢神经系统。近年研究发现,神经炎症反应会导致神经中枢过度活动,其中肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)对神经递质传递、Ca~(2+)内流、神经元突触结构和功能重组有重要影响,可能在急性耳鸣发病机制中起到关键性诱发作用。本文就TNF-α与急性耳鸣发病的中枢机制进行探讨。
关键词
耳鸣;肿瘤坏死因子-α;神经重塑;神经递质;Ca~(2+)
基金项目(Foundation):
上海市进一步加快中医药事业发展三年行动计划[ZY(2021-2023)-0208]
作者
徐智辉;霍岩;凌雯琛;张剑宁
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