首页 > 当期目录 > 文章详情

COVID-19感染后远期听力损失及耳鸣的研究

Study on long-term hearing loss and tinnitus after COVID-19 infection

王浩璇;王宇;潘滔;赵威;兰可馨;王旭;袁亦方

1:北京大学第三医院

2:北京大学医学部

在线阅读

摘要

目的分析新型冠状病毒(coronavirus disease 2019,COVID-19)感染后远期听力损失及耳鸣的发生率、听力学特征及影响因素，探究COVID-19对听觉系统的远期影响。方法以感染过COVID-19的成年人761例为研究对象，在症状问卷和专科查体后，对其中感染后新发听力损失和/或耳鸣且症状持续超过3～6个月的患者进行纯音听阈测试、声导抗、耳声发射等检查，分析年龄、基础疾病等因素与听觉系统症状的相关性。结果 761例中分别有60例(7.88%)、79例(10.38%)感染后有新发听力损失、耳鸣症状，其中分别有38例(4.99%)、33例(4.34%)在新发听力损失或耳鸣后远期(3～6个月)症状仍存在。卡方检验显示，年龄、糖尿病、既往听力损失史与感染后听力损失有相关性；高脂血症、失眠、既往耳鸣史、感染次数与感染后耳鸣有相关性。听力学检查提示，在感染后新发听力损失的45耳中，感音神经性听力损失12耳(26.67%),隐性听力损失25耳(55.56%),低频听力损失3耳(6.67%),高频听力损失4耳(8.89%),传导性听力损失1耳(最终确诊为耳硬化症)。结论 COVID-19感染后新发的听力损失和耳鸣可在远期持续存在。高龄、糖尿病及有听力损失史者是COVID-19感染后新发听力损失的高危人群；多次感染、有耳鸣史和失眠者是感染后新发耳鸣的高危人群。

关键词

新型冠状病毒;听力损失;耳鸣;远期

基金项目(Foundation):

北京大学第三医院创新转化基金(BYSYZHKC 2022111)

作者

王浩璇;王宇;潘滔;赵威;兰可馨;王旭;袁亦方

参考文献

[1] LIU F,LIU F,WANG L.COVID-19 and cardiovascular diseases[J].J Mol Cell Biol,2021,13(3):161-167.

[2] CHAU A S,WEBER A G,MARIA N I,et al.The longitudinal immune response to coronavirus disease 2019:chasing the cytokine storm[J].Arthritis Rheumatol,2021,73(1):23-35.

[3] HARRISON P J,TAQUET M.Neuropsychiatric disorders following SARS-CoV-2 infection[J].Brain,2023,146(6):2241-2247.

[4] SRIWIJITALAI W,WIWANITKIT V.Hearing loss and COVID-19:a note[J].Am J Otolaryngol,2020,41(3):102473.

[5] KILIC O,KALCIOGLU M T.Could sudden sensorineural hearing loss be the sole manifestation of COVID-19 An investigation into SARS-CoV-2 in the etiology of sudden sensorineural hearing loss[J].Int J Infect Dis,2020,97:208-211.

[6] FIDAN V,AKIN O,KOYUNCU H.Rised sudden sensorineural hearing loss during COVID-19 widespread[J].Am J Otolaryngol,2021,42(5):102996.

[7] LI H,XIA J,BENNETT D.Long-COVID-19 clinical and health outcomes:an umbrella review[J].Ther Adv Infect Dis,2023,10:20499361231198335.

[8] ZEHRA A,GAUTAM H K.Irreversible sensorineural hearing loss in post COVID-19 patients-an institutional prospective study[J].Indian J Otolaryngol Head Neck Surg,2023,75:424-428.

[9] 陈知己，袁伟，刘雪莱，等.中文版听力障碍量表评估不同年龄听障患者主观听障程度的应用价值[J].听力学及言语疾病杂志，2022,30(4):379-383.

[10] JAFARI Z,KOLB B E,MOHAJERANI M H.Hearing loss,tinnitus,and dizziness in COVID-19:a systematic review and meta-analysis[J].Can J Neurol Sci,2022,49(2):184-195.

[11] ??Z??ELIK K M,E■ILMEZ O K.Otolaryngological manifestations of hospitalised patients with confirmed COVID-19 infection[J].Eur Arch Otorhinolaryngol,2021,278(5):1675-1685.

[12] ELIBOL E.Otolaryngological symptoms in COVID-19[J].Eur Arch Otorhinolaryngol,2021,278(4):1233-1236.

[13] FRENI F,MEDURI A,GAZIA F,et al.Symptomatology in head and neck district in coronavirus disease (COVID-19):a possible neuroinvasive action of SARS-CoV-2[J].Am J Otolaryngol,2020,41(5):102612.

[14] VIOLA P,RALLI M.Tinnitus and equilibrium disorders in COVID-19 patients:preliminary results[J].Eur Arch Otorhinolaryngol,2021,278(10):3725-3730.

[15] KARADA?? ??,??ZT??RK B,SONKAYA A R.A prospective clinical study of detailed neurological manifestations in patients with COVID-19[J].Neurol Sci,2020,41(8):1991-1995.

[16] CHARI D A,PARIKH A,KOZIN E D,et al.Impact of COVID-19 on presentation of sudden sensorineural hearing loss at a single institution[J].Otolaryngol Head Neck Surg,2021,165(1):163-165.

[17] ALMUFARRIJ I,MUNRO K J.One year on:an updated systematic review of SARS-CoV-2,COVID-19 and audio-vestibular symptoms[J].Int J Audiol,2021,60(12):935-945.

[18] 中华耳鼻咽喉头颈外科杂志编辑委员会，中华医学会耳鼻咽喉头颈外科学分会.突发性聋诊断和治疗指南(2015)[J].中华耳鼻咽喉头颈外科杂志，2015,50(6):443-447.

[19] 刘懿萱，于慧前，李华伟.中、美、德三国突发性聋诊疗指南的解读与分析[J].中华耳鼻咽喉头颈外科杂志，2023,58(6):637-642.

[20] JARACH C M,LUGO A,SCALA M,et al.Global pre-valence and incidence of tinnitus[J].JAMA Neurol,2022,79(9):888-900.

[21] LIBERMAN M C.Hidden hearing loss[J].Sci Am,2015,313(2):48-53.

[22] 冀飞.隐性听力损失—临床听力学的新挑战(2)·诊治现状与面临问题[J].听力学及言语疾病杂志，2018,26(4):339-343.

[23] 吴成琪，唐冬梅，孙珊.老年性听力损失研究进展及应对策略[J].听力学及言语疾病杂志，2022,30(2):219-224.

[24] CHEN Y,KLEIN S L.Aging in COVID-19:vulnerability,immunity and intervention[J].Ageing Res Rev,2021,65:101205.

[25] LI R,SHEN M,YANG Q,et al.Global diabetes prevalence in COVID-19 patients and contribution to COVID-19- related severity and mortality:a systematic review and meta-analysis[J].Diabetes Care,2023,46(4):890-897.

[26] KAZAKOU P,LAMBADIARI V.Diabetes and COVID-19:a bidirectional interplay[J].Front Endocrinol (Lausanne),2022,13:780663.

[27] SAMOCHA B D,WU B,RYUGO D K.Diabetes mellitus and hearing loss:a review[J].Ageing Res Rev,2021,71:101423.

[28] GU H,KONG W,YIN H,et al.Prevalence of sleep impairment in patients with tinnitus:a systematic review and single-arm meta-analysis[J].Eur Arch Otorhinolaryngol,2022,279(5):2211-2221.

[29] AWAD M,ABDALLA I,JARA S M,et al.Association of sleep characteristics with tinnitus and hearing loss[J].OTO Open,2024,8(1):e117.

[30] BEUKES E W,BAGULEY D M.Changes in tinnitus experiences during the COVID-19 pandemic[J].Front Public Health,2020,8:592878.

[31] XIA L,HE G,FENG Y,et al.COVID-19 associated anxiety enhances tinnitus[J].PLoS One,2021,16(2):e0246328.

[32] PATTYN T,VAN D E F.Tinnitus and anxiety disorders:a review[J].Hear Res,2016,333:255-265.

[33] ZIAI K,MOSHTAGHI O,MAHBOUBI H,et al.Tinnitus patients suffering from anxiety and depression:a review[J].Int Tinnitus J,2017,21(1):68-73.

[34] KOZYK M,NAVOLOKINA A,BONDARENKO A.Risk of cardiovascular events and death according to COVID-19 reinfection[J].Cardiol J,2023,30(3):495-496.

本文信息

PDF(182K)

本文关键词相关文章

新型冠状病毒听力损失耳鸣远期

本文作者相关文章

王浩璇王宇潘滔赵威兰可馨王旭袁亦方