水凝胶载体在内耳药物递送的最新研究进展

The latest research progress of hydrogel carrier in inner ear drug delivery

张培丽;刁明芳

1:中国人民解放军总医院第六医学中心耳鼻咽喉头颈外科医学部耳内镜外科

2:华南理工大学医学院

3:国家耳鼻咽喉疾病临床医学研究中心

摘要
内耳疾病的治疗面临着生理屏障的困扰。相较于全身给药治疗内耳疾病,局部给药更具有高效性,然而因为药物易经咽鼓管流失,亟需新的药物载体,以提高药物运输至内耳的效率。水凝胶作为一种局部给药递送系统,具有持续和可控药物释放的优势,可最大限度地提高药物扩散,同时减少药物消除的个体差异。本文将综述各种类型水凝胶的研究进展,总结各种水凝胶的优点及局限性,为开发有效治疗内耳疾病的水凝胶载体提供参考。
关键词
内耳;水凝胶;药物递送
基金项目(Foundation):
首都卫生发展科研专项基金资助(首发-2022-2-5072)
作者
张培丽;刁明芳
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内耳水凝胶药物递送

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张培丽刁明芳