STING棕榈酰化抑制剂C176在保护HEI-OC1细胞氧化损伤中的作用及机制研究
Study on the role and mechanism of STING palmitoylation inhibitor C176 in protecting HEI-OC1 cells against oxidative damage
陈筱颖;王洁;张园园;华清泉
1:武汉大学人民医院耳鼻咽喉头颈外科武汉大学耳鼻咽喉头颈外科研究所
[1] PRASAD K N,BONDY S C.Increased oxidative stress,inflammation,and glutamate:potential preventive and therapeutic targets for hearing disorders[J].Mech Ageing Dev,2020,185:111191.DOI:10.1016/j.mad.2019.111191
[2] TERAOKA M,HATO N,INUFUSA H,et al.Role of oxidative stress in sensorineural hearing loss[J].Int J Mol Sci,2024,25.DOI:10.3390/ijms25084146
[3] 赵章,陈竹香.线粒体钙单向转运蛋白在HEI-OC1细胞氧化损伤中的作用[J].听力学及言语疾病杂志,2025,33(5):460-464.
[4] LIU J,CHEN H,LIN X,et al.Age-related activation of cyclic GMP-AMP synthase-stimulator of interferon genes signaling in the auditory system is associated with presbycusis in C57BL/6J male mice[J].Neuroscience,2022,481:73-84.DOI:10.1016/j.neuroscience.2021.11.031
[5] CHEN Q,SUN L,CHEN Z J.Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing[J].Nat Immunol,2016,17(10):1142-1149.
[6] HANSEN A L,MUKAI K,SCHOPFER F J,et al.STING palmitoylation as a therapeutic target[J].Cell Mol Immunol,2019,16(3):236-241.
[7] FETONI A R,PACIELLO F,ROLESI R,et al.Targeting dysregulation of redox homeostasis in noise-induced hearing loss:oxidative stress and ROS signaling[J].Free Radic Biol Med,2019,135:46-59.
[8] 王光辉,徐贝贝,许鸾,等.SIRT1/PGC-1α通路在D-半乳糖诱导的HEI-OC1细胞氧化应激损伤过程中的调控机制[J].听力学及言语疾病杂志,
[9] BHATTI J S,BHATTI G K,REDDY P H.Mitochondrial dysfunction and oxidative stress in metabolic disorders—a step towards mitochondria based therapeutic strategies[J].Biochim Biophys Acta Mol Basis Dis,2017,1863(5):1066-1077.
[10] GILL N B,DOWKER-KEY P D,HEDRICK M,et al.Unveiling the role of oxidative stress in cochlear hair cell death:prospective phytochemical therapeutics against sensorineural hearing loss[J].Int J Mol Sci,2024,25(8):4272.
[11] DI CARA F,SAVARY S,KOVACS W J,et al.The peroxisome:an up-and-coming organelle in immunometabolism[J].Trends Cell Biol,2023,33(1):70-86.
[12] DELMAGHANI S,DEFOURNY J,AGHAIE A,et al.Hypervulnerability to sound exposure through impaired adaptive proliferation of peroxisomes[J].Cell,2015,163(4):894-906.
[13] SUN T,WANG D,WANG B,et al.Melatonin attenuates cisplatin-induced acute kidney injury in mice:involvement of PPARα and fatty acid oxidation[J].Food Chem Toxicol,2022,163:112970.DOI:10.1016/j.fct.2022.112970
[14] FUJINAMI Y,MUTAI H,MIZUTARI K,et al.A novel animal model of hearing loss caused by acute endoplasmic reticulum stress in the cochlea[J].J Pharmacol Sci,2012,118(3):363-372.
[15] CHEN H,LIN C,XUE H M,et al.The heat shock protein DNAJB2 as a novel biomarker for essential thrombocythemia diagnosis associated with immune infiltration[J].Thromb Res,2023,223:131-138.DOI:10.1016/j.thromres.2023.01.029
[16] SU C,CHENG T,HUANG J,et al.4-Octyl itaconate restricts STING activation by blocking its palmitoylation[J].Cell Rep,2023,42(9):113040.
[17] KANG J,WU J,LIU Q,et al.FASN regulates STING palmitoylation via malonyl-CoA in macrophages to alleviate sepsis-induced liver injury[J].Biochim Biophys Acta Mol Basis Dis,2024,1870(7):167299.
[18] YAN S B,LIANG H,ZHAN P,et al.Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation[J].J Cachexia Sarcopenia Muscle,2023,14(6):2623-2641.
[19] ACOSTA-ALVEAR D,HARNOSS J M,WALTER P,et al.Homeostasis control in health and disease by the unfolded protein response[J].Nat Rev Mol Cell Biol,2025,26:193-212.
[20] LIU Y,LI Z,ZHANG J,et al.DYNLL1 accelerates cell cycle via ILF2/CDK4 axis to promote hepatocellular carcinoma development and palbociclib sensitivity[J].Br J Cancer,2024,131(2):243-257.
[21] LI W,CHEN J,XIONG Z,et al.Dynactin 2 acts as an oncogene in hepatocellular carcinoma through promoting cell cycle progression[J].Liver Res,2022,6(3):155-166.
[22] KULOW V A,ROEGNER K,LABES R,et al.Beyond hemoglobin:critical role of 2,3-bisphosphoglycerate mutase in kidney function and injury[J].Acta Physiol (Oxf),2025,241(1):e14242.
[23] ZHU T,LIU B,WU D,et al.Autophagy regulates VDAC3 ubiquitination by FBXW7 to promote erastin-induced ferroptosis in acute lymphoblastic leukemia[J].Front Cell Dev Biol,2021,9:740884.DOI:10.3389/fcell.2021.740884

