尿高氯酸盐、硝酸盐、硫氰酸盐暴露与儿童及青少年听力的相关性研究

Study on the correlation between urinary perchlorate, nitrate and thiocyanate exposure and hearing ablilities in children and adolescents

边迪;李灏然;王乐;李玲;叶放蕾

1:郑州大学第一附属医院耳科

2:郑州大学第五附属医院耳鼻咽喉科

摘要
目的 探究儿童及青少年群体中尿高氯酸盐、硝酸盐和硫氰酸盐水平与听力的相关性。方法 统计美国国家健康和营养调查(NHANES)数据库2005~2020年间共4 445例6~19岁人群的纯音听阈(pure-tone audiometry, PTA)及其尿高氯酸盐、硝酸盐和硫氰酸盐的数据,评估此3种化合物浓度与听力的潜在关系。结果 在受试者总体中,尿高氯酸盐浓度与语频听力损失风险呈负相关;硝酸盐在男性群体中与语频听力损失风险呈正相关,而在女性中呈负相关;硫氰酸盐在无反复耳部感染史的受试者中与语频听力损失风险呈负相关,而在有反复感染史的受试者中呈正相关。尿高氯酸盐及硫氰酸盐浓度与高频听阈之间存在“L”型的非线性关系。结论 尿高氯酸盐浓度适度增高,儿童和青少年听力损失的风险可能降低;而硝酸盐及硫氰酸盐在不同浓度及群体中,与听力的相关性不尽相同。
关键词
儿童;青少年;高氯酸盐;硝酸盐;硫氰酸盐;听力
基金项目(Foundation):
作者
边迪;李灏然;王乐;李玲;叶放蕾
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