豚鼠耳蜗外侧壁周细胞的分布及形态学观察
Morphological study of pericytes in the lateral wall of cochlea in guinea pig
范术杭;塞娜;孙健斌;王琴;郭维维;韩维举
1:中国人民解放军医学院
2:中国人民解放军总医院第六医学中心耳鼻咽喉头颈外科医学部
3:听觉与平衡觉全国重点实验室
4:国家耳鼻咽喉疾病临床医学研究中心
[1] COSENTINO A,AGAFONOVA A,MODAFFERI S,et al.Blood-labyrinth barrier in health and diseases:effect of hormeticnutrients[J].Antioxidants Redox Signaling,2024,40(7-9):542-563.
[2] MATSYA R T,JACQUELINE M O,ALAIN D.Hearing function,degeneration,and disease:spotlight on the striavascularis[J].Frontiers in Cell and Developmental Biology,2022,10:841708.DOI:10.3389/fcell.2022.841708
[3] GAO Y M,WU F,HE W H,et al.ROS-related disruptions to cochlear hair cell and striavascularis consequently leading to radiation-induced sensorineural hearing loss[J].Antioxidants Redox Signaling,2024,40(7-9):470-491.
[4] 张呈辉,任芳芳,王伟韬,等.血-迷路屏障通透性与突聋发病机制及预后的关系:在3D real IR的发现[J].听力学及言语疾病杂志,2024,32(3):236-240.
[5] 陈林军,邱士伟,龙熙,等.Mitf-M基因突变对猪耳蜗血管纹发育的影响[J].中华耳科学杂志,2018,16(4):483-487.
[6] CARMELINA D A,ALESSIA C,ALEKSANDRA A,et al.Pericytes of striavascularisare targets of cisplatin-induced ototoxicity:new insights into the molecular mechanisms involved in blood-labyrinth barrier breakdown[J].International Journal of Molecular Sciences,2022,23(24):15790.DOI:10.3390/ijms232415790
[7] 塞娜,张桐,吴军,等.小鼠耳蜗血管纹血-迷路屏障免疫组织化学研究[J].中华耳科学杂志,2018,16(2):205-211.
[8] NENG L L,ZHANG J H,YANG J,et al.Structural changes in thestrial blood-labyrinth barrier of aged C57BL/6 mice[J].Cell and Tissue Research,2015,361(3):685-696.
[9] 曹扬,王洪阳,李丹阳,等.国内近30年噪声性听力损失研究状况分析[J].听力学及言语疾病杂志,2025,33(3):265-269.
[10] 邓双,董波,徐少然,等.C57BL/6J小鼠衰老耳蜗血管纹微血管周细胞对内皮细胞通透性影响的研究[J].中华耳鼻咽喉头颈外科杂志,2021,56(11):1185-1193.
[11] 高险亭,卢岭,梁耕田,等.老化型C57BL/6J小鼠耳蜗外侧壁血管纹Claudin-5、 NF-κB、P21的表达[J].听力学及言语疾病杂志,2021,29(3):334-337.
[12] 张桐,韩维举.耳蜗血管纹血-迷路屏障病理生理学研究进展[J].中华耳科学杂志,2017,15(2):257-262.
[13] SHI X,WANG Z H,REN W,et al.LDL receptor-related protein 1 (LRP1),a novel target for opening the blood-labyrinth barrier (BLB)[J].Signal Transduction and Targeted Therapy,2022,7(1):175.
[14] 吴军,韩维举.耳蜗血-迷路屏障与噪声性听力损伤[J].听力学及言语疾病杂志,2015,23(4):427-430.
[15] BIRBRAIR A,ZHANG T,WANG Z M,et al.Pericytes at the intersection between tissue regeneration and pathology[J].Clinical Science (London),2015,128(2):81-93.
[16] LUIS A M,MUGE Y,TURGAY D.Pericyte morphology and function[J].Histology and Histopathology,2021,36(6):633-643.
[17] 刘艳辉,王艳萍,王洋,等.豚鼠耳蜗血管纹周细胞电生理特性的研究[J].中华耳鼻咽喉头颈外科杂志,2016,51(8):600-605.
[18] SHI X.Pathophysiology of the cochlear intrastrial fluid-blood barrier (review)[J].Hearing Research,2016,338:52-63.
[19] CANIS M,BERTLICH M.Cochlear capillary pericytes[J].Advances in Experimental Medicine and Biology,2019,1122:115-123.
[20] KURELI G,YILMAZ O S,ERDENER S E,et al.F-actin polymerization contributes to pericyte contractility in retinal capillaries[J].Experimental Neurology,2020,332:113392.DOI:10.1016/j.expneurol.2020.113392
[21] NUNZIA C,FLORIANA D A,MARIA T C,et al.Pericytes in microvessels:from “mural” function to brain and retina regeneration[J].International Journal of Molecular Sciences,2019,20(24):6351.DOI:10.3390/ijms20246351
[22] 塞娜,张桐,吴军,等.噪声引起的豚鼠血-迷路屏障损伤及基质金属蛋白酶抑制剂的保护作用[J].中华耳鼻咽喉头颈外科杂志,2020,55(4):363-370.
[23] HOU Z Q,NENG L L,ZHANG J H,et al.Acoustic trauma causes cochlear pericyte-to-myofibroblast-like cell transformation and vascular degeneration,and transplantation of new pericytesprevents vascular atrophy[J].The American Journal of Pathology,2020,190(9):1943-1959.
[24] TROST A,LANGE S,SCHROEDL F,et al.Brain and retinal pericytes:origin,function and role[J].Frontiers in Cellular Neuroscience,2016,10:20.DOI:10.3389/fncel.2016.00020
[25] BHATTACHARYA A,KAUSHIK D K,LOZINSKI B M,et al.Beyond barrier functions:roles of pericytes in homeostasis and regulation of neuroinflammation[J].Journal of Neuroscience Research,2020,98(12):2390-2405.
[26] ZHANG J,HOU Z,WANG X,et al.VEGFA165 gene therapy ameliorates blood-labyrinth barrier breakdown and hearing loss[J].Frontiers in Cell and Developmental Biology,2021,6(8):841708.DOI:10.3389/fcell.2022.841708
[27] 孙韬,李悦淇,石科,等.噪声性听力损失机制研究方法及药物治疗进展[J].听力学及言语疾病杂志,2024,32(3):283-288.

