肠道菌群失调对耳鸣相关中枢神经递质影响的研究进展

Research progress on the impact of gut microbiota dysbiosis on central neurotransmitters associated with tinnitus

古毅勋;胡莹;龚桃根;柯朝阳

1:南方科技大学医学院

2:南方科技大学第一附属医院(深圳市人民医院)耳鼻咽喉科

3:暨南大学第二临床医学院

4:深圳市人民医院耳鼻咽喉科

摘要
近年研究表明,γ-氨基丁酸(gama-aminobutyric acid, GABA)、5-羟色胺(serotonin, 5-HT)和多巴胺作为抑制性神经递质、谷氨酸作为兴奋性神经递质,可以影响听觉中枢的“兴奋-抑制”平衡导致耳鸣,肠道菌群失调可以通过改变神经递质水平进而影响耳鸣的发生及发展。部分菌群的丰度增加可提高GABA、谷氨酸的浓度,葡萄球菌、双歧杆菌等菌群能促进5-HT的合成,齿双歧杆菌等菌群丰度下降可能导致中枢多巴胺浓度降低。本文综述了与耳鸣相关的中枢神经递质以及肠道菌群失调对这些神经递质的影响,试图通过揭示肠道菌群失调与耳鸣的潜在关联,为耳鸣的机制研究及预防和治疗提供新思路。
关键词
耳鸣;肠道菌群;肠脑轴;神经递质
基金项目(Foundation):
作者
古毅勋;胡莹;龚桃根;柯朝阳
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古毅勋胡莹龚桃根柯朝阳