单侧突发性聋患者脑磁共振扩散峰度成像研究

Diffusion Kurtosis Imaging Study in Patients with Unilateral Sudden Sensorineural Hearing Loss

严齐;关兵;

1:扬州大学临床医学院苏北人民医院

摘要
目的探讨单侧突发性聋患者脑部磁共振弥散峰度成像(diffasion kurtosis imaging, DKI)检查对突聋预后的评估作用。方法收集右侧突发性聋患者32例(突聋组),(病程≤3周,男16例,女16例,年龄39~73岁,平均52.31±8.59岁),正常对照组23例(男11例,女12例,年龄41~68岁,平均56.36±6.82岁),对照组和突聋组治疗前行常规磁共振检查及全脑DKI成像扫描;基于统计软件比较突聋组与正常对照组全脑DKI各参数图差异脑区;并根据治疗结果,将突聋组患者分为显效组(20例)和无效组(12例),再分别与正常对照组比较。结果双样本t检验结果显示,与正常对照组比较,突聋组左侧的颞上回、颞中回及颞下回、左侧的顶叶及枕叶等脑区的白质有不同程度的各向异性分数(FA)值减小,突聋组双侧额叶均有平均扩散峰度(MK)值及径向峰度(RK)值增加。突聋组的显效组20例和无效组12例分别与正常对照组比较,可见突聋组的轴向分度(AD)在右侧额上回、右侧额中回、左侧额中回减小,右侧中央后回减小,径向分度(RD)在左侧扣带回、左侧颞上回减小,扩散峰度各向异性(KFA)在左侧枕上回、左侧角回、左侧扣带回增加,平均弥散率(MD)在右侧额叶直回增加,MK在左侧边缘叶、右侧额中回、右侧缘上回增大,这些区域的改变提示预后较好;AD、RD、KFA、MD、MK在颞上、中、下回减小,而枕叶、额叶无改变,则提示预后较差。结论 DKI检查对突发性聋的预后评估有一定的指导作用,颞叶、额叶、枕叶均发生参数改变的患者预后较佳,参数改变发生在颞叶的患者,则其预后较差。

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关键词
突发性聋;磁共振成像;脑部磁共振弥散峰度成像;听觉皮层
基金项目(Foundation):
苏北人民医院级基金(yzucms202029)
作者
严齐;关兵;
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