噪声性聋机制及潜在分子治疗的研究现状
范贝;陆菲;查定军;
1:空军军医大学第一附属医院西京医院耳鼻咽喉头颈外科





1 Basner M,Babisch W,Davis A,et al.Auditory and non-auditory effects of noise on health[J].Lancet,2014,383(9925):1325-1332.
2 Yamashita D,Jiang HY,Schacht J,et al.Delayed production of free radicals following noise exposure[J].Brain Res,2004,1019(1-2):201-209.
3 Sha SH,Schacht J.Emerging therapeutic interventions against noise-induced hearing loss[J].Expert Opin Investig Drugs,2017,26(1):85-96.
4 Fetoni AR,Paciello F,Rolesi R,et al.Targeting dysregulation of redox homeostasis in noise-induced hearing loss:Oxidative stress and ROS signaling[J].Free Radic Biol Med,2019,135:46-59.https://pubmed.ncbi.nlm.nih.gov/30802489/.
5 Pak JH,Yi J,Ryu S,et al.Induction of redox-active gene expression by CoCl2 ameliorates oxidative stress-mediated injury of murine auditory cells[J].Antioxidants (Basel),2019,8(9):399-418.
6 Shi X.Resident macrophages in the cochlear blood-labyrinth barrier and their renewal via migration of bone-marrow-derived cells[J].Cell Tissue Res,2010,342(1):21-30.
7 Brown LN,Xing Y,Noble KV,et al.Macrophage-mediated glial cell elimination in the postnatal mouse cochlea[J].Front Mol Neurosci,2017,10:407-427.https://pubmed.ncbi.nlm.nih.gov/29375297/.
8 He W,Yu J,Sun Y,et al.Macrophages in noise-exposed cochlea:changes,regulation and the potential role[J].Aging Dis,2020,11(1):191-199.
9 Vethanayagam RR,Yang W,Dong Y,et al.Toll-like receptor 4 modulates the cochlear immune response to acoustic injury[J].Cell Death Dis,2016,7(6):e2245-2256.
10 Kalinec GM,Lomberk G,Urrutia R A,et al.Resolution of cochlear inflammation:novel target for preventing or ameliorating drug-,noise-and age-related hearing loss[J].Front Cell Neurosci,2017,11:192-216.https://pubmed.ncbi.nlm.nih.gov/28736517/.
11 Zhang G,Zheng H,Pyykko I,et al.The TLR-4/NF-κB signaling pathway activation in cochlear inflammation of rats with noise-induced hearing loss[J].Hear Res,2019,379:59-68.https://pubmed.ncbi.nlm.nih.gov/31096078/
12 Fridberger A,Flock A,Ulfendahl M,et al.Acoustic overstimulation increases outer hair cell Ca2+ concentrations and causes dynamic contractions of the hearing organ[J].Proc Natl Acad Sci USA,1998,95(12):7127-7132.
13 Uemaetomari I,Tabuchi K,Nakamagoe M,et al.L-type voltage-gated calcium channel is involved in the pathogenesis of acoustic injury in the cochlea[J].Tohoku J Exp Med,2009,218(1):41-47.
14 Prell CG,Yamashita D,Minami S,et al.Mechanisms of noise-induced hearing loss indicate multiple methods of prevention[J].Hear Res,2007,226(1-2):22-43.
15 Wang J,Pignol B,Chabrier P E,et al.A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma[J].Neuropharmacology,2007,52(6):1426-1437.
16 Sliwinska-Kowalska M,Pawelczyk M.Contribution of genetic factors to noise-induced hearing loss:a human studies review[J].Mutat Res,2013,752(1):61-65.
17 Shen H,Huo X,Liu K,et al.Genetic variation in GSTM1 is associated with susceptibility to noise-induced hearing loss in a Chinese population[J].J Occup Environ Med,2012,54(9):1157-1162.
18 Loukzadeh Z,Sani HE,Sheikhha MH,et al.Association of GST gene polymorphism and noise-induced hearing loss:GST gene polymorphism and NIHL[J].AIMS Public Health,2019,6(4):546-553.
19 Tuerdi A,Kinoshita M,Kamogashira T,et al.Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice[J].Neurosci Lett,2017,642:123-128.https://pubmed.ncbi.nlm.nih.gov/28163078/.
20 Zhang X,Ni Y,Liu Y,et al.Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility[J].Environ Health,2019,18(1):30-38.
21 Xu XR,Wang JJ,Yang QY,et al.The effect of PCDH15 gene variations on the risk of noise-induced hearing loss in a Chinese population[J].Biomed Environ Sci,2017,30(2):143-146.
22 杨秋月,徐相蓉,焦洁,等.GRHL2 基因多态性与噪声性听力损失易感性的关系[J].北京大学学报 (医学版),2016,48(3):409-413.
23 Sliwinskakowalska M,Pawelczyk M.Contribution of genetic factors to noise-induced hearing loss:a human studies review[J].Mutat Res,2013,752(1):61-65.
24 Lei S,Huang L,Liu Y,et al.Association between polymorphisms of heat-shock protein 70 genes and noise-induced hearing loss:a meta-analysis[J].PLoS One,2017,12(11):e0188539-e0188555.
25 Guo H,Ding E,Sheng R,et al.Genetic variation in KCNQ4 gene is associated with susceptibility to noise-induced hearing loss in a Chinese population[J].Environ Toxicol Pharmacol,2018,63:55-59.https://pubmed.ncbi.nlm.nih.gov/30153627/.
26 Zheng F,Zuo J.Cochlear hair cell regeneration after noise-induced hearing loss:does regeneration follow development[J].Hear Res,2017,349:182-196.https://pubmed.ncbi.nlm.nih.gov/28034617/.
27 Ma Y,Wise AK,Shepherd RK,et al.New molecular therapies for the treatment of hearing loss[J].Pharmacol Ther,2019,200:190-209.https://pubmed.ncbi.nlm.nih.gov/31075354/
28 Eshraghi AA,Jung HD,Mittal R.Recent advancements in gene and stem cell-based treatment modalities:potential implications in noise-induced hearing Loss[J].Anat Rec (Hoboken),2020,303(3):516-526.
29 Pfannenstiel SC,Praetorius M,Plinkert PK,et al.Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells[J].Audiol Neurootol,2009,14(4):254-266.
30 Liu Z,Dearman J A,Cox B C,et al.Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression[J].J Neurosci,2012,32(19):6600-6610.
31 Liu Z,Fang J,Dearman J,et al.In vivo generation of immature inner hair cells in neonatal mouse cochleae by ectopic Atoh1 expression[J].PLoS One,2014,9(2):e89377-e89389.
32 Walters BJ,Coak E,Dearman J,et al.In vivo interplay between p27(Kip1),GATA3,ATOH1,and POU4F3 converts non-sensory cells to hair cells in adult mice[J].Cell Rep,2017,19(2):307-320.
33 Kawamoto K,Ishimoto S,Minoda R,et al.Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo[J].J Neurosci,2003,23(11):4395-4400.
34 Mizutari K,Fujioka M,Hosoya M,et al.Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma[J].Neuron,2013,77(1):58-69.
35 Honkura Y,Matsuo H,Murakami S,et al.NRF2 is a key target for prevention of noise-induced hearing loss by reducing oxidative damage of cochlea[J].Sci Rep,2016,6:19329-19341.https://pubmed.ncbi.nlm.nih.gov/26776972/.
36 Mittal R,Debs LH,Nguyen D,et al.Signaling in the auditory system:implications in hair cell regeneration and hearing function[J].J Cell Physiol,2017,232(10):2710-2721.
37 Atkinson PJ,Wise AK,Flynn BO,et al.Neurotrophin gene therapy for sustained neural preservation after deafness[J].PLoS One,2012,7(12):e52338-e52348.
38 Chen H,Xing Y,Xia L,et al.AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy[J].Gene Ther,2018,25(4):251-259.
39 Li H,Liu H,Heller S.Pluripotent stem cells from the adult mouse inner ear[J].Nat Med,2003,9(10):1293-1299.
40 Perny M,Ting CC,Kleinlogel S,et al.Generation of otic sensory neurons from mouse embryonic stem cells in 3D Culture[J].Front Cell Neurosci,2017,11:409-421.https://pubmed.ncbi.nlm.nih.gov/29311837/.
41 DeJonge RE,Liu XP,Deig CR,et al.Modulation of wnt signaling enhances inner ear organoid development in 3D culture[J].PLoS One,2016,11(9):e0162508-e0162522.
42 Cho YB,Cho HH,Jang S,et al.Transplantation of neural differentiated human mesenchymal stem cells into the cochlea of an auditory-neuropathy guinea pig model[J].J Korean Med Sci,2011,26(4):492-498.
43 Fetoni AR,Lattanzi W,Eramo SL,et al.Grafting and early expression of growth factors from adipose-derived stem cells transplanted into the cochlea,in a Guinea pig model of acoustic trauma[J].Front Cell Neurosci,2014,8:334-348.https://pubmed.ncbi.nlm.nih.gov/25368551/.
44 Ishikawa M,Ohnishi H,Skerleva D,et al.Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae[J].J Tissue Eng Regen Med,2017,11(6):1766-1778.
45 Chen JR,Tang ZH,Zheng J,et al.Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation[J].Cell Death Differ,2016,23(8):1347-1357.
46 Youm I,Li W.Cochlear hair cell regeneration:an emerging opportunity to cure noise-induced sensorineural hearing loss[J].Drug Discov Today,2018,23(8):1564-1569.
47 Qiu Y,Qiu J.Stem Cells:a new hope for hearing loss therapy[J].Adv Exp Med Biol,2019,1130:165-180.https://pubmed.ncbi.nlm.nih.gov/30915707/.