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178例先天性巨细胞病毒感染患儿听力评估及随访

Hearing Evaluation and Follow-up Study of 178 Children with Congenital Cytomegalovirus Infection

潘旭烽;刘云亮;林祥航;丁诗华;陈靖垚;

1:福建省儿童医院耳鼻咽喉科

2:福建省妇幼保健院福建医科大学附属医院耳鼻咽喉科

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摘要

目的探讨先天性巨细胞病毒(congenital cytomegalovirus, cCMV)感染患儿听力损失特点。方法对178例诊断为先天性巨细胞病毒感染的患儿，采用自动听性脑干反应(AABR)行新生儿听力筛查，未通过者42天复筛，并于3、6、9、12、18、24、30及36月龄时进行随访，随访过程中AABR听力筛查未通过的患儿进行听力诊断，包括专科检查、畸变产物耳声发射(DPOAE)、声导抗、听性脑干反应(ABR)检测。结果 178例cCMV感染患儿中诊断感音神经性听力损失(SNHL)16例(8.99%,16/178),症状型感染患儿的听力损失检出率(28.57%,8/28)明显高于无症状感染患儿(5.33%,8/150);单侧9例，双侧7例，其中中重度及以上听力损失者分别为66.67%(6/9)和57.14%(4/7);先天性SNHL 5例(31.25%,5/16),迟发性SNHL11例(68.75%,11/16),其中中重度及以上听力损失7例；波动性SNHL2例(其中1例随访过程中听力恢复正常),渐进性SNHL5例，其余9例在随访期间表现为平稳性SNHL。结论 cCMV感染患儿SNHL发生率较高，且多表现为中重度及以上程度听力损失，症状型感染患儿的听力损失更明显；迟发性SNHL所占比例较大，听力损失初始时间多在婴幼儿早期，应密切随访，及早发现并干预。

关键词

先天性巨细胞病毒感染;听力损失;随访

基金项目(Foundation):

作者

潘旭烽;刘云亮;林祥航;丁诗华;陈靖垚;

参考文献

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先天性巨细胞病毒感染听力损失随访

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潘旭烽刘云亮林祥航丁诗华陈靖垚