围绝经期女性BPPV与骨代谢生化指标的相关性研究

Correlation Study of BPPV and Changes of Bone Metabolism Biochemical Index in Perimenopausal Women

王田;邢巍巍;

1:锦州医科大学附属第一医院耳鼻咽喉头颈外科

摘要

目的探讨围绝经期女性特发性良性阵发性位置性眩晕(iBPPV)与骨代谢生化指标之间的关系。方法选取围绝经期iBPPV患者105例作为病例组，随访1年，依据有无复发分为未复发组85例，复发组20例；并选取同期围绝经期健康女性50例作为对照组；对比三组血清雌二醇、25-羟维生素D、血钙浓度、Ⅰ型胶原氨基端延长肽(P1NP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、骨钙素水平，对围绝经期iBPPV患者血清雌二醇与骨代谢生化指标之间的关系进行Pearson相关分析。结果 (1)对照组雌二醇、血钙浓度与25-羟维生素D水平明显高于未复发组和复发组，差异均有统计学意义(均为P<0.05);对照组P1NP、β-CTX、骨钙素水平与未复发组和复发组差异均无统计学意义(均为P>0.05)。复发组雌二醇、血钙浓度与25-羟维生素D水平明显低于未复发组，差异均有统计学意义(均为P<0.05);(2)围绝经期iBPPV患者血清中雌二醇与P1NP、骨钙素、血钙浓度及25-羟维生素D水平均呈明显正相关关系(分别为r=0.775,r=0.583,r=0.630,r=0.674,均为P<0.01),与β-CTX水平呈明显负相关关系(r=-0.717,P<0.01);(3)Logistic回归分析结果显示复位次数(OR=13.091)、SDS评分(OR=17.875)、就诊时眩晕时间(OR=4.800)、雌二醇(OR=0.859)、血钙浓度(OR=0.000)及25-羟维生素D(OR=0.676)为围绝经期女性iBPPV复发的易感因素。结论血清中雌二醇、血钙浓度和25-羟维生素D水平下降的围绝经期女性易发生iBPPV,且更易复发。

关键词

围绝经期;特发性良性阵发性位置性眩晕;雌激素;骨代谢生化指标

基金项目(Foundation):

作者

王田;邢巍巍;

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围绝经期特发性良性阵发性位置性眩晕雌激素骨代谢生化指标

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王田邢巍巍