siRNA抑制GPX1表达对新霉素诱导HEI-OC1细胞凋亡的影响
Effect of Inhibition GPX1 by siRNA on Apoptosis of HEI-OC1 Cells Induced by Neomycin
陈放;王雪峰;
1:锦州医科大学附属第一医院耳鼻咽喉头颈外科
1 Laurell G.Pharmacological intervention in the field of ototoxicity[J].HNO,2019,67(6):434-439.
2 Ruhl D,Du TT,Wanger EL,et al.Necroptosis and apoptosis contribute to cisplatin and aminoglycoside ototoxicity[J].J Neurosci,2019,39(15):2951-2964.
3 Choung YH,Taura A,Pak K,et al.Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin[J].Neuroscience,2009,161(1):214-226.
4 Wang J,Van De Water TR,Bonny C,et al.A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss[J].J Neurosci,2003,23(24):8596-8607.
5 Warchol ME.Cellular mechanisms of aminoglycoside ototoxicity[J].Curr Opin Otolaryngol Head Neck Surg,2010,18(5):454-458.
6 Aktar K,Kafi A,Dahiya R.Association of GPX1 fluctuation in cell cycle progression[J].In Vitro Cell Dev Biol Anim,2019,55(2):94-103.
7 Mai HN,Jeong JH,Kim DJ,et al.Genetic overexpressing of GPx-1 attenuates cocaine-induced renal toxicity via induction of anti-apoptotic factors[J].Clin Exp Pharmacol Physiol,2016,43(4):428-437.
8 McFadden SL,Ohlemiller KK,Ding D,et al.The Influence of Superoxide Dismutase and Glutathione Peroxidase Deficiencies on Noise-Induced Hearing Loss in Mice[J].Noise Health,2001,3(11):49-64.
9 Kil J,Pierce C,Tran H,et al.Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase[J].Hear Res,2007,226(1-2):44-51.
10 Coffin AB,Rubel EW,Raible DW.Bax,Bcl2,and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line[J].J Assoc Res Otolaryngol,2013,14(5):645-659.
11 Yan Y,Jiang W,Tan Y,et al.hucMSC exosome-derived GPX1 is required for the recovery of hepatic oxidant injury[J].Mol Ther,2017,25(2):465-479.
12 de Haan JB,Bladier C,Lotfi-Miri M,et al.,Fibroblasts derived from GPX1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death[J].Free Radic Biol Med,2004,36(1):53-64.
13 Zheng Z,Wang Y,Yu H,et al.Salvianolic acid B inhibits ototoxic drug-induced ototoxicity by suppression of the mitochondrial apoptosis pathway[J].J Cell Mol Med,2020,24(12):6883-6897.
14 He Y,Yu H,Cai C,et al.Inhibition of H3K4me2 demethylation protects auditory hair cells from neomycin-induced apoptosis[J].Mol Neurobiol,2015,52(1):196-205.
15 Czabotar PE,Lessen G,Strasser A,et al.Control of apoptosis by the Bcl-2 protein family:implications for physiology and therapy[J].Nat Rev Mol Cell Biol,2014,15(1):49-63.
16 Youle RJ,Strasser A.The Bcl-2 protein family:opposing activities that mediate cell death[J].Nat Rev Mol Cell Biol,2008,9(1):47-59.