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梅尼埃病患者外周血IL-10、IL-4、IFN-γ、IL-17水平的研究

王汝嬿;韩晓丽;屈永涛;李色;郭明丽;

1:山东省耳鼻喉医院眩晕疾病科

2:山东大学

3:河北省人民医院

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摘要

目的通过检测梅尼埃病(Meniere’s disease, MD)患者外周血清Ⅰ型变态反应相关因子的表达，探讨Ⅰ型变态反应在MD发病机制中可能的作用。方法以31例MD患者为MD组(年龄33～77岁),耳科正常受试者18例为对照组(年龄30～69岁),用酶联免疫吸附法检测两组血清中白介素-10(interleukin-10,IL-10)、白介素-4(interleukin-4,IL-4)、干扰素-γ(interferon-γ,IFN-γ)、白介素-17(interleukin-17,IL-17)、总免疫球蛋白E(total immunogloblin E,tIgE)水平，比较两组结果。结果 MD组tIgE阳性率明显高于对照组(51.61%vs 16.67%,P<0.05),两组间血清IL-4、IFN-γ、IL-17、IL-10浓度差异无统计学意义(P>0.05)。MD组IL-4/IFN-γ高于对照组(1.00±0.23 vs 0.73±0.23),IL-17/IL-10高于对照组(0.29±0.07 vs 0.24±0.07),差异均有统计学意义(P<0.05)。结论 Ⅰ型变态反应可能是部分MD患者重要的发病原因之一；IL-4/IFN-γ、IL-17/IL-10失衡在部分MD患者发病中起重要作用。

关键词

梅尼埃病;白介素-4;干扰素-γ;白介素-10;白介素-17;免疫球蛋白E

基金项目(Foundation):

作者

王汝嬿;韩晓丽;屈永涛;李色;郭明丽;

参考文献

1 Fang D,Zhu J.Molecular switches for regulating the differentiation of inflammatory and IL-10-producing anti-inflammatory T-helper cells[J].Cell Mol Life Sci,2020,77(2):289-303.

2 中华耳鼻咽喉头颈外科杂志编辑委员会，中华医学会耳鼻咽喉头外科学分会.梅尼埃病诊断和治疗指南(2017)[J].中华耳鼻咽喉头颈外科杂志，2017,52(3):167-172.

3 Egami N,Kakigi A,Takeda T,et al.Type 1 allergy-induced endolymphatic hydrops and the suppressive effect of H1-receptor antagonist (olopatadine hydrochloride)[J].Otol Neurotol,2014,35(3):e104-109.

4 M?ller MN,Kirkeby S,Vikesa J,et al.Expression of histamine receptors in the human endolymphatic sac:the molecular rationale for betahistine use in Meniere’s disease[J].Eur Arch Otorhinolaryngol,2016,273(7):1705-1710.

5 潘滔，赵宇，丁玉静，等.梅尼埃病患者中Ⅰ型变态反应检测的初步研究[J].中华耳鼻咽喉头颈外科杂志，2017,52(2):89-92.

6 姚玉婷，严道南.鼻敏感方对变应性鼻炎模型大鼠血清IL-17及IL-10含量的影响[J].中华中医药杂志，2016,31(3):1041-1044.

7 Wang WW,Zhu K,Yu HW,et al.Interleukin-17A potentiates interleukin-13-induced eotaxin-3 production by human nasal epithelial cells from patients with allergic rhinitis[J].Int Forum Allergy Rhinol,2019,9(11):1327-1333.

8 Coomes SM,Kannan Y,Pelly VS,et al.CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation[J].Mucosal Immunol,2017,10(1):150-161.

9 Mai J,Liang B,Xiong Z,et al.Oral administration of recombinant Bacillus subtilis spores expressing helicobacter pylori neutrophil-activating protein suppresses peanut allergy via up-regulation of Tregs[J].Clin Exp Allergy,2019,49(12):1605-1614.

10 Xu F,Yu S,Qin M,et al.Hydrogen-rich saline ameliorates allergic rhinitis by reversing the imbalance of Th1/Th2 and up-regulation of CD4+CD25+Foxp3+regulatory T cells,interleukin-10,and membrane-bound transforming growth factor-β in guinea pigs[J].Inflammation,2018,41(1):81-92.

11 Dehnavi S,Azad FJ,Hoseini RF,et al.A significant decrease in the gene expression of interleukin-17 following the administration of synbiotic in patients with allergic rhinitis who underwent immunotherapy:a placebo-controlled clinical trial[J].J Res Med Sci,2019,24:51.

12 Salmani A,Mohammadi M,Farid Hosseini R,et al.A significant increase in expression of FOXP3 and IL-17 genes in patients with allergic rhinitis underwent accelerated rush immunotherapy[J].Iran J Basic Med Sci,2019,22(9):989-996.

13 苗青，陈曦，任亦欣，等.花粉症患者在季节发作期外周血Th17/Treg细胞的平衡变化及其临床意义[J].中华微生物学和免疫学杂志，2017,37(5):355-360.

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梅尼埃病白介素-4 干扰素-γ 白介素-10 白介素-17 免疫球蛋白E

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王汝嬿韩晓丽屈永涛李色郭明丽