系统免疫炎症指数对突发性聋患者预后的影响

Effect of Systemic Immune-inflammatory Index and the Prognosis of Patients with Sudden Deafness

黄巧;任毅;侯涛;廖行伟;尹时华;

1:广西医科大学第二附属医院耳鼻咽喉头颈外科

摘要
目的 探讨中性粒细胞与淋巴细胞之比(NLR)、血小板与淋巴细胞之比(PLR)、系统免疫炎症指数(systemic immune inflammation index, SII)对突发性聋预后的影响。方法 100例单侧突发性聋确诊患者根据治疗效果分为有效组59例和无效组41例,采用单因素和多因素Logistic分析比较两组治疗前的NLR、PLR、SII;采用ROC曲线法分析白细胞计数、中性粒细胞计数、NLR和SII对突发性聋患者预后的预测价值,并确定其最佳截断值。结果 单因素分析结果显示突发性聋预后与听阈曲线分型、听力损失程度、白细胞计数、中性粒细胞计数、NLR、SII有关(P<0.05),而与初诊时间、住院天数、性别、年龄、单核细胞计数、淋巴细胞计数、血小板无关(P>0.05)。采用二元Logistic回归分析进行影响因素分析,结果显示白细胞计数、中性粒细胞计数、NLR、SII为突发性聋预后的影响因素。ROC曲线分析结果显示,白细胞计数、中性粒细胞计数、NLR、SII预测突发性聋患者预后不良的AUC面积分别为0.850、0.875、0.792、0.800。结论 NLR、SII对突发性聋患者的预后具有一定的预测作用。
关键词
突发性聋;中性粒细胞与淋巴细胞之比(NLR);血小板与淋巴细胞之比(PLR);系统免疫炎症指数(SII);预后
基金项目(Foundation):
国家自然科学基金(82160213);; 广西卫计委自筹课题(Z20191075);; 广西中医药管理局课题(GZZC2020192)
作者
黄巧;任毅;侯涛;廖行伟;尹时华;
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