正常听力儿童及青年失匹配负波研究

Mismatch Negativity In Normal Children and Youth

朱斌;孟子珅;胡萍萍;关兵;

1:扬州大学医学院临床学院苏北人民医院耳鼻咽喉头颈外科

摘要
目的探讨正常儿童及正常青年失匹配负波(mismatch negativity,MMN)的特点。方法对29例(58耳)正常听力儿童(7~16岁)及29例(58耳)正常听力青年(18~34岁)采用经典的oddball模式进行MMN检查,标准刺激和偏差刺激分别为1 000 Hz和2 000 Hz的短纯音,观察两组MMN潜伏期及波幅的特点,并比较两组的差异。结果 58例(116耳)受试者均可正常引出MMN波形,正常儿童组MMN平均潜伏期和平均波幅分别为171.23±26.90 ms和3.46±2.30μV,正常青年组分别为177.57±26.61 ms和3.96±2.46μV;两组间MMN潜伏期及波幅均无统计学差异(P=0.072,P=0.11>0.05)。结论 7~16岁正常听力儿童及18~34岁正常听力青年组均能引出稳定的MMN波形,且两组间MMN的潜伏期和波幅无明显差异;MMN结果与儿童受试者听觉通路的成熟情况有关,与年龄差异无关。
关键词
失匹配负波;纯音测听;听性脑干反应;听觉中枢
基金项目(Foundation):
作者
朱斌;孟子珅;胡萍萍;关兵;
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