血白细胞及C-反应蛋白对评价突发性聋发病及预后的作用

The Role of Leukocyte and CRP in the Pathogenesis and Prognosis of Sudden Deafness

吴静;张海燕;王亚娜;王书谦;杨文婧;

1:沧州医学高等专科学校外科护理教研室

2:沧州市人民医院耳鼻喉科

摘要
目的探讨血白细胞(WBC)及C-反应蛋白(C-reaction protein,CRP)与突发性聋发病及预后的关系。方法选取突发性聋患者162例,按照入院血常规检查结果及是否应用抗生素治疗,分为WBC正常组78例(WBC≤10×109/L),给予常规治疗;高WBC常规治疗组42例(WBC>10×109/L),给予常规治疗;高WBC常规治疗组42例(WBC>10×109/L),给予常规治疗;高WBC联合治疗组42例(WBC>10×109/L),给予常规治疗;高WBC联合治疗组42例(WBC>10×109/L),给予常规治疗同时联合抗生素治疗。分别检测三组患者治疗前后纯音听阈,比较治疗前后WBC及CRP水平的变化。结果高WBC常规治疗组有效率85.7%,高WBC联合治疗组有效率83.3%,均高于白细胞正常组的64.1%,差异有统计学意义(P<0.05);高WBC常规治疗组与高WBC联合治疗组有效率差异无统计学意义(P>0.05)。高WBC常规治疗组和高WBC联合治疗组治疗后WBC和CRP含量较治疗前均显著降低,差异均有统计学意义(P<0.05);但两组间治疗前后WBC和CRP水平相比,差异均无统计学意义(P>0.05)。低频下降型突聋患者中WBC升高者比例较其他听阈曲线类型者高,且治疗总有效率高于高频下降型和全频下降型患者。结论突聋的发病可能与炎症相关,但不是细菌感染引起的炎症反应,可能是机体的应激系统或免疫系统发挥作用,白细胞升高患者的治疗效果好于白细胞正常者,对白细胞升高的突聋患者采用抗生素治疗无临床意义。
关键词
白细胞;C-反应蛋白;突发性聋
基金项目(Foundation):
沧州市级课题(172302138)
作者
吴静;张海燕;王亚娜;王书谦;杨文婧;
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