胶质细胞源性神经营养因子在听觉相关系统中作用的研究进展

周爽;廖华;

1:武汉大学人民医院耳鼻咽喉头颈外科

摘要

<正>神经营养因子是影响神经元发育和维持神经可塑性的重要因子,胶质细胞源性神经营养因子(glial cell line derived neurotrophic factor,GDNF)是由胶质细胞衍生的神经营养因子,是一种糖基化、二硫键结合的同型二聚体蛋白,是转化生长因子-β超家族的成员,具有支持神经元的生长,助于神经元的存活和分化,并抑制细胞死亡的作用,可以保护听觉系统的感觉细胞免受噪声的破坏等([1])。因GDNF对多巴胺能神经元、运动神经元、感觉神经元等明显的神经营养作用,目前已经成为治疗帕金森病、肿瘤等疾病的研究热点([1])。因GDNF对多巴胺能神经元、运动神经元、感觉神经元等明显的神经营养作用,目前已经成为治疗帕金森病、肿瘤等疾病的研究热点([2,3])。在胚胎发育和成熟动物的耳蜗神经元及毛细胞内均检测到GDNF的mRNA和蛋白的表达,而GDNF的表达量在噪声损伤和缺血等情况下升高,证明其潜在的内源性神经营养因子保护作用([2,3])。在胚胎发育和成熟动物的耳蜗神经元及毛细胞内均检测到GDNF的mRNA和蛋白的表达,而GDNF的表达量在噪声损伤和缺血等情况下升高,证明其潜在的内源性神经营养因子保护作用([4])。GDNF在与听觉系统相关的组织中均有表达,如下丘、海马、上橄榄复合体等,目前关于GDNF在听觉系统等神经营养作用的研究成为热点,并可能有助于临床治疗内耳疾病,本文对GDNF在听觉系统相关组织中的作用进行综述。

关键词

基金项目(Foundation):

国家自然科学基金面上项目(30772397);; 湖北省自然科学基金面上项目(2015CFB718)

作者

周爽;廖华;

参考文献

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周爽廖华