去泛素化酶在喉癌及舌癌中的作用及机制研究

王洁;华清泉;

1:武汉大学人民医院耳鼻咽喉头颈外科

摘要
<正>喉鳞状细胞癌(LSCC)与舌鳞状细胞癌(TSCC)是发生于人体言语发声器官中较为常见的肿瘤,其致病因素十分复杂,包括烟草和酒精摄入、人乳头瘤病毒(HPV)或EB病毒(EBV)等病毒感染、辐射、牙周疾病、维生素缺乏症和饮食习惯(Pezzuto,2015)。在过去的十年中,经过分子和细胞遗传学研究证明,各种癌基因和抑癌基因的突变或异常表达促进了喉癌及舌癌的恶性表型,因此,分子水平的深入研究有利于喉癌及舌癌患者的合理治疗,为其治疗提供了新的思路和方法。
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王洁;华清泉;
参考文献

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王洁华清泉