中耳胆脂瘤中DAPI核染色、FOXO3和Bim的表达和意义
Expression and Significance of DAPI Staining, FOXO3 and Bim in Middle Ear Cholesteatoma
刘东亮;马秀岚;
1:中国医科大学附属盛京医院耳鼻咽喉科





[1] Chetverikov PE,Desnitskiy AG.A study of embryonic development in eriophyoid mites(Acariformes,Eriophyoidea)with the use of the fluorochrome DAPI and confocal microscopy[J].Exp Appl Acarol,2016,68(1):97-111.
[2] Yagi K,Pawekowicz M,Osipowski P,et al.Molecular cytogenetic analysis of cucumis wild species distributed in southern africa:physical mapping of 5Sand 45SrDNA with DAPI[J].Cytogenet Genome Res,2015,146(1):80-87.
[3] Zhang X,Tang N,Hadden TJ,et al.Akt,FoxO and regulation of apoptosis[J].Biochim Biophys Acta,2011,1813(11):1978-1986.
[4] Birkenkamp KU,Coffer PJ.Regulation of cell survival and proliferation by the FOXO(Forkhead box,class O)subfamily of Forkhead transcription factors[J].Biochem Soc Trans,2003,31(Pt 1):292-297.
[5] Zhang X,Rielland M,Yalcin S,et al.Regulation and function of FoxO transcription factors in normal and cancer stem cells:what have we learned[J].Curr Drug Targets,2011,12(9):1267-1283.
[6] Strasser A,Vaux DL.Viewing Bcl2and cell death control from an evolutionary perspective[J].Cell Death Differ,2018,25(1):13-20.
[7] Park M,Lee B,Lee J.Expression of tumor necrosis factor-like weak inducer of apoptosis in human middle ear cholesteatoma[J].ORL J Otorhinolaryngol Relat Spec,2013,75(4):221-227.
[8] Zhang W,Chen X,Qin Z.MicroRNA let-7asuppresses the growth and invasion of cholesteatoma keratinocytes[J].Mol Med Rep,2015,11(3):2097-2103.
[9] Kim KH,Lim HJ,Kim YJ,et al.The oncoprotein,gankyrin,is up-regulated in middle ear cholesteatoma[J].Acta Otolaryngol,2014,134(3):238-243.
[10] Szczepanski MJ,Luczak M,Olszewska E,et al.Molecular signaling of the HMGB1/RAGE axis contributes to cholesteatoma pathogenesis[J].J Mol Med(Berl),2015,93(3):305-314.
[11] Wang Z,Yu T,Huang P.Post-translational modifications of FOXO family proteins(Review)[J].Mol Med Rep,2016,14(6):4931-4941.
[12] Tzivion G,Dobson M,Ramakrishnan G.FoxO transcription factors;regulation by AKT and 14-3-3proteins[J].Biochim Biophys Acta,2011,1813(11):1938-1945.
[13] Wang J,Liu S,Yin Y,et al.FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis[J].Apoptosis,2015,20(3):399-409.
[14] Martinou JC,Youle RJ.Mitochondria in apoptosis:Bcl-2family members and mitochondrial dynamics[J].Dev Cell,2011,21(1):92-101.
[15] Maimaiti Y,Dong L,Aili A,et al.Bim may be a poor prognostic biomarker in breast cancer patients especially in those with luminal A tumors[J].Cancer Biomark,2017,19(4):411-418.
[16] Wu F,Lin Y,Cui P,et al.Cdc20/p55mediates the resistance to docetaxel in castration-resistant prostate cancer in a Bimdependent manner[J].Cancer Chemother Pharmacol,2018,81(6):999-1006.
[17] Baumgartner U,Berger F,Hashemi Gheinani A,et al.miR-19benhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2Aand BIM in nonsmall cell lung cancer[J].Mol Cancer,2018,17(1):44-44.
[18] Wu CC,Bratton SB.Regulation of the intinsic opoptosis pathway by reactive oxygen species[J].Antioxid Redox Signal,2013,19(6):546-558.
[19]刘东亮,马秀岚.PTEN及P-ERK和P-AKT在中耳胆脂瘤上皮中的表达及意义[J].临床耳鼻咽喉头颈外科杂志,2014,28(4):238-242.