汉语发展性阅读障碍儿童不同听觉刺激模式下事件相关电位特征分析

The Characteristics of Event-related Potential in Chinese Dyslexia with Different Stimulus Modes

邓柯高;雷湘;张一新;唐淑婷;左彭湘;

1:新疆石河子大学医学院护理系

2:新疆喀什市育才小学

3:陆军第九四七医院特诊科

摘要
目的比较汉语发展性阅读障碍(development dyslexia,DD)儿童和正常对照组儿童失匹配负波(mismatch negativity,MMN)、P1-N1c-N2的差异,探讨发展性阅读障碍儿童不同听觉刺激模式下事件相关电位的特征。方法在标准刺激(纯音,上升时间15 ms,强度75 dB SPL,持续时间200 ms,P=0.85)的基础上,分别调整刺激声的上升时间、强度和持续时间形成三种偏差刺激(P=0.15),采用被动Oddball范式对22例汉语DD儿童(DD组)和31例正常对照儿童(对照组)进行脑电图(EEG)采集,比较DD组和对照组MMN与P1-N1c-N2成分的差异。结果 FCz电极点的分析:①DD组上升时间偏差刺激(P=0.026<0.05)和持续时间偏差刺激下(P=0.037<0.05)MMN波幅均小于对照组;②DD组中上升时间偏差刺激P1潜伏期较标准刺激延迟(P=0.011<0.05),而对照组中差异不显著;③DD组上升时间偏差刺激N2波幅小于标准刺激(P=0.002<0.01),而对照组差异不显著;④DD组持续时间偏差刺激N2波幅小于标准刺激(P<0.001),而对照组差异不显著。FT7和FT8电极N1c波幅存在差异,DD组持续时间偏差刺激N1c波幅小于标准刺激(P=0.009<0.05),而对照组差异不显著,其他交互作用不显著。结论发展性阅读障碍儿童的听觉分辨能力较正常儿童差,上升时间偏差刺激和持续时间偏差刺激下MMN和P1-N1c-N2潜伏期延长、波幅降低,发展性阅读障碍儿童可能存在听觉感知障碍。
关键词
发展性阅读障碍;事件相关电位;失匹配负波;儿童
基金项目(Foundation):
国家自然科学基金项目(81760597)
作者
邓柯高;雷湘;张一新;唐淑婷;左彭湘;
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