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皮层听觉诱发电位评估人工耳蜗植入语前聋儿童的中枢听觉系统发育

Central Auditory Development: Evidence from CAEP Measurements in the Congenitally Deaf Children after Cochlear Implants

王兴龙;王春芳;张平;郑烨贤;毛忠瑶;刘爱国;

1:华中科技大学同济医学院附属武汉中心医院耳鼻喉科

2:华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科

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摘要

目的研究人工耳蜗植入语前聋儿童的皮层听觉诱发电位(cortical auditory evoked potential, CAEP)P1波潜伏期的发展规律,评估不同年龄段植入人工耳蜗语前聋儿童的中枢听觉系统的发育。方法以人工耳蜗植入语前聋儿童50例(植入年龄15～66月,平均38.7±15.2月,其中小于42月龄者27例,大于42月龄者23例)和年龄相匹配的正常听力儿童50例为研究对象,采用500、1 000、2 000、4 000 Hz四种频率的短纯音(tone burst,TB)刺激声分别对受试者进行皮层听觉诱发电位测试,并对人工耳蜗植入语前聋儿童进行婴幼儿有意义听觉整合量表或有意义听觉整合量表(infant-toddler meaningful auditory integration scale/meamingful auditory integration scale,IT-MAIS/MAIS)评分,比较两组P1波潜伏期,对P1波潜伏期和IT-MAIS/MAIS评分进行相关性分析。结果正常听力儿童四种不同频率短纯音刺激记录的CAEP P1波潜伏期与年龄均呈负相关(P<0.01);42月龄前植入人工耳蜗的语前聋儿童P1波潜伏期与正常听力儿童无统计学差异(P>0.05);42月龄以后植入人工耳蜗的语前聋儿童的P1波潜伏期较正常儿童显著延长,差异有显著统计学意义(P<0.01)。人工耳蜗植入儿童的CAEP P1波潜伏期与IT-MAIS/MAIS量表评分均呈负相关(P<0.01),不同频率TB刺激声下的P1波潜伏期无统计学差异(P>0.05)。结论大于42月龄植入人工耳蜗的语前聋儿童的中枢听觉系统发育较正常听力儿童延迟。

关键词

皮层听觉诱发电位;人工耳蜗植入;语前聋;P1波潜伏期

基金项目(Foundation):

国家自然科学基金项目（81271072）

作者

王兴龙;王春芳;张平;郑烨贤;毛忠瑶;刘爱国;

参考文献

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皮层听觉诱发电位人工耳蜗植入语前聋 P1波潜伏期

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王兴龙王春芳张平郑烨贤毛忠瑶刘爱国