亨廷顿症患者的言语障碍及其治疗

潘雪瑶;姜孟;

1:四川外国语大学研究生院/语言脑科学研究中心

2:四川外国语大学语言脑科学研究中心/语言智能学院

摘要
<正>亨廷顿症(Huntington's disease, HD)是一种常染色体显性遗传病,由基因HTT的突变引起。患者的大脑病变部位始于基底神经节,其中尾状核和壳核体积变化明显,此外,纹状体多巴胺D1、 D2受体的丧失将导致纹状体回路功能障碍,以额叶-纹状体回路受损最突出;随着病程的发展,在大脑的其他皮层下和皮质区域(如颞叶)也观察到细胞数量的减少[1]。患者一般在40岁左右发病,也有非常年轻或非常年长发病的病例,病情呈进行性恶化,通常在发
关键词
基金项目(Foundation):
重庆市研究生科研创新项目(CYB18177)资助
作者
潘雪瑶;姜孟;
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潘雪瑶姜孟