GJB2基因突变致聋患者人工耳蜗植入后疗效的Meta分析

Meta Analysis of the Efficacy of Cochlear Implantation in Deafness Patients with GJB2 Gene Mutation

徐丽;关兵;张俊中;王莹;郭思荃;

1:江苏省苏北人民医院耳鼻喉头颈外科

摘要
目的评价GJB2基因突变致聋患者人工耳蜗植入后的疗效。方法选用Pubmed、Web of science、 Embase、Cochrane Library、CNKI、维普、中国知网及万方等数据库检索2000~2019年国内外发表的GJB2基因突变致聋患儿人工耳蜗植入效果评估的病例对照研究,采用NOS量表(评价对象选择、组间可比性、暴露因素)评价文献质量,得分≥5分者纳入研究,纳入文献应用RevMan5.3统计软件进行Meta统计分析。结果共纳入12篇文献,NOS量表评分6~8分,Meta分析显示,术后GJB2基因突变组与对照组婴幼有意义听觉整合量表(IT-MAIS)得分(突变组108例,对照组168例)(MD=2.95,95%CI为-0.10~6.01,P=0.06)、言语可懂度分级(SIR)得分(突变组102例,对照组154例)(MD=0.16,95%CI为-0.24~0.57,P=0.42)、听觉行为分级(CAP)得分(突变组161例,对照组250例)(MD=0.24,95%CI为-0.08~0.56,P=0.14)差异无统计学意义。结论 GJB2基因突变致聋患者人工耳蜗植入术后疗效与非GJB2基因突变致聋患者基本一致,人工耳蜗植入可作为GJB2基因突变致聋患者的常规治疗手段,术后效果满意。
关键词
GJB2基因突变;人工耳蜗植入;Meta分析
基金项目(Foundation):
扬州市重点研发计划(社会发展)YZ2106084项目资助
作者
徐丽;关兵;张俊中;王莹;郭思荃;
参考文献

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