水杨酸钠诱导耳鸣大鼠海马中TNF-α、IL-1β的表达
The Expression of TNF-α and IL-1β in the Hippocampus of Rats with Tinnitus Induced by Salicylate
肖倩文;左健;葛佳丽;王采集;李雅兰;李婷;乔月华;
1:徐州医科大学
2:徐州医科大学形态学研究中心
3:江苏省人工听觉工程实验室
4:徐州医科大学附属医院
摘要关键词基金项目(Foundation):作者参考文献1 Bhatt JM,Bhattacharyya N,Lin HW.Relationships between tinnitus and the prevalence of anxiety and depression[J].Laryngoscope,2017,127:466.
2 Norena AJ,Farley BJ.Tinnitus-related neural activity:theories of generation,propagation,and centralization[J].Hearing Research,2013,295:161.
3 Elgoyhen AB,Langguth B,De RD,et al.Tinnitus:perspectives from human neuroimaging[J].Nature Reviews Neuroscience,2015,16:700.
4 Yi B,Hu S,Zuo C,et al.Effects of long-term salicylate administration on synaptic ultrastructure and metabolic activity in the rat CNS[J].Scientific Reports,2016,6:24428.
5 Vitlic A,Lord JM,Phillips AC.Stress,ageing and their influence on functional,cellular and molecular aspects of the immune system[J].AGE,2014,36:867.
6 Szczepek AJ,Haupt H,Klapp BF,et al.Biological correlates of tinnitus-related distress:an exploratory study[J].Hearing Research,2014,318:23.
7 Hwang JH,Chen JC,Yang SY,et al.Expression of tumor necrosis factor-α and interleukin-1β genes in the cochlea and inferior colliculus in salicylate-induced tinnitus[J].Journal of Neuroinflammation,2011,8:30.
8 Kawasaki Y,Zhang L,Cheng JK,et al.Cytokine mechanisms of central sensitization:distinct and overlapping role of interleukin-1β,interleukin-6,and tumor necrosis factor-α in regulating synaptic and neuronal activity in the superficial spinal cord[J].Journal of Neuroscience,2008,28:5189.
9 Niu H,Ding S,Li H,et al.Effect of long-term sodium salicylate administration on learning,memory,and neurogenesis in the rat hippocampus[J].Bio Med Research International,2018,2018:1.
10 尹时华,唐安洲,谭颂华,等.水杨酸钠对幼年和成年豚鼠听性脑干反应阈值及螺旋神经节谷氨酸脱羧酶表达的影响[J].中华耳鼻咽喉头颈外科杂志,2008,43:364.
11 Robinson SK,Viirre ES,Stein MB.Antidepressant therapy in tinnitus[J].Hear Res,2007,226:221.
12 Park KM,Bowers WJ.Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction[J].Cellular Signalling,2010,22:977.
13 Katsuki H,Nakai S,Hirai Y,et al.Interleukin-1β inhibits long-term potentiation in the CA3 region of mouse hippocampal slices[J].European Journal of Pharmacology,1990,181:323.
14 于林,禤正正,吴升伟,等.加味逍遥散对抑郁大鼠行为学及海马组织炎症因子表达的影响[J].新中医,2017,49:9.
15 Wang N,Yu HY,Shen XF,et al.The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus[J].Upsala Journal of Medical Sciences,2015,120:241.
16 胡守森,梅玲,陈建勇,等.水杨酸盐毒性与大鼠耳蜗核炎症因子表达[J].中华耳科学杂志,2015,13:143.
17 Monyer H,Burnashev N,Laurie DJ,et al.Developmental and regional expression in the rat brain and functional properties of four NMDA receptors[J].Neuron,1994,12:529.
18 Zhang SJ,Zou M,Lu L,et al.Nuclear calcium signaling controls expression of a large gene pool:identification of a gene program for acquired neuroprotection induced by synaptic activity[J].PLoS Genetics,2009,5:e1000604.
19 解为全,廖华,杨希林,等.水杨酸钠致耳鸣大鼠脑海马区促肾上腺皮质激素释放因子的表达[J].听力学及言语疾病杂志,2013,21:167.
20 Jara JH,Singh BB,Floden AM,et al.Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death [J].Journal of Neurochemistry,2007,100:14.
21 Viviani B,Bartesaghi S,Gardoni F,et al.IL-1β enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases[J].Journal of Neuroscience,2003,23:8692.