NELL2a在斑马鱼神经丘的表达及其突变模型构建
Expression of NELL2a in Zebrafish Neuromast and Construction of Its Mutation Model
陈二方;邱阳;王人凤;刘珍珍;石力;查定军;邱建华;
1:中国人民解放军空军军医大学第一附属医院耳鼻咽喉头颈外科





1 Oyasu M,Kuroda S,Nakashita M,et al.Immunocytochemical localization of a neuron-specific thrombospondin-1-like protein,NELL2:light and electron microscopic studies in the rat brain[J].Molecular Brain Research,2000,76:151.
2 赵昱,石力,王剑,等.常染色体显性遗传性听神经病基因突变筛查[J].中华耳科学杂志,2014,12:267.
3 王锦玲,石力,薛飞,等.听神经病听力学特征及病损部位分析[J].听力学及言语疾病杂志,2007,14:89.
4 Jao LE,Wente SR,Chen W.Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system[J].Proc Natl Acad Sci USA,2013,110:13904.
5 Da L,Zhanxiang W,An X,et al.Efficient gene targeting in zebrafish mediated by a zebrafish-codon-optimized cas9 and evaluation of off-targeting effect[J].Journal of Genetics and Genomics,2014,41:41.
6 张峰华,王厚鹏,黄思雨,等.两种密码子优化的Cas9编码基因在斑马鱼胚胎中基因敲除效率的比较[J].遗传,2016,38:144.
7 Chang N,Sun C,Gao L,et al.Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos[J].Cell Res,2013,23:465.
8 Thisse C,Thisse B.High-resolution in situ hybridization to whole-mount zebrafish embryos[J].Nat Protoc,2008,3:59.
9 潘豪来,王际平,于栋帧,等.斑马鱼听觉诱发电位检测系统的建立和应用[J].听力学及言语疾病杂志,2017,25:269.
10 Manchaiah VK,Zhao F,Danesh AA,et al.The genetic basis of auditory neuropathy spectrum disorder (ANSD)[J].International Journal of Pediatric Otorhinolaryngology,2011,75:151.
11 Ha CM,Choi J,Choi EJ,et al.NELL2,a neuron-specific EGF-like protein,is selectively expressed in glutamatergic neurons and contributes to the glutamatergic control of GnRH neurons at puberty[J].Neuroendocrinology,2008,88:199.
12 Kim DG,Hwang EM,Yoo JC,et al.Identification and characterization of a truncated isoform of NELL2[J].Biochem Biophys Res Commun,2010,391:529.
13 Montgomery J,Cartion G,Voigt R,et al.Sensory processing of water currents by fishes[J].Biological Sciences,2000,355:1325.
14 Metcalfe WK,Kimmel CB,Schabtach E.Anatomy of the posterior lateral line system in young larvae of the zebrafish[J].J Comp Neurol,1985,233:377.
15 Romero-Carvajal A,Acedo JN,Jiang L,et al.Regeneration of sensory hair cells requires localized interactions between the Notch and wnt pathways[J].Developmental Cell,2015,34:267.
16 Raible DW,Kruse GJ.Organization of the lateral line system in embryonic zebrafish[J].J Comp Neurol,2000,421:189.
17 Kim H,Ha CM,Choi J,et al.Ontogeny and the possible function of a novel epidermal growth factor-like repeat domain-containing protein,NELL2,in the rat brain[J].J Neurochem,2002,83:1389.
18 周莎莎.NELL2及其在促性腺激素释放激素分泌中的作用[J].国际儿科学杂志,2011,38:162.