先天性外中耳畸形(12)——耳郭软骨成分与生物力学性能

张天宇;卢鑫雨;傅窈窈;

1:复旦大学附属眼耳鼻喉科医院眼耳鼻整形外科

2:复旦大学附属眼耳鼻喉科医院耳鼻喉科研究院

摘要
<正>耳郭软骨组织工程是先天性外中耳畸形修复的重要研究方向之一,可以避免肋软骨切取所造成的供区并发症,并减少因术者支架雕刻水平而造成的耳郭外形差异。软骨组织工程经过近20年的发展,在种子细胞、支架材料、细胞因子三方面均进行了积极的探索,但组织工程软骨生物力学性能不足,不能对抗皮瓣的回缩仍是限制其临床转化的重要瓶颈。除由脂肪组织构成的耳垂外,耳郭软骨存在于耳郭的所有部位,并被软骨膜所包围。耳郭软骨属于弹性软骨,其细胞外基质成分和组织形态与透
关键词
基金项目(Foundation):
国家自然科学基金面上项目(81771014)
作者
张天宇;卢鑫雨;傅窈窈;
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张天宇卢鑫雨傅窈窈